Snijders Tim, Nederveen Joshua P, Verdijk Lex B, Houben Alfons J H M, Goossens Gijs H, Parise Gianna, van Loon Luc J C
Department of Human Biology and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands.
Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Physiol Rep. 2017 May;5(10):e13278. doi: 10.14814/phy2.13278.
To investigate the association between muscle fiber capillarization and indices of insulin sensitivity in healthy older adults. A skeletal muscle biopsy was taken from the of 22 healthy (nondiabetic) male older adults. In addition, all participants underwent an Oral Glucose Tolerance Test (OGTT). Muscle fiber capillarization was assessed by immunohistochemistry. Participants were divided into a group with relatively low (LOW) or high (HIGH) muscle fiber capillarization (capillary-to-fiber perimeter exchange (CFPE) index), based on the median value for the entire group. All participants were healthy, nonobese, and had a normal glucose tolerance, according to the individual OGTT results. Whereas no differences in blood glucose concentrations were observed between groups during the OGTT, the postprandial increase in plasma insulin concentrations was significantly greater in the LOW compared to the HIGH muscle fiber capillarization group ( < 0.05). Skeletal muscle fiber capillarization may determine insulin sensitivity in humans.
为研究健康老年人肌肉纤维毛细血管化与胰岛素敏感性指标之间的关联。从22名健康（非糖尿病）老年男性的 处采集了骨骼肌活检样本。此外，所有参与者均接受了口服葡萄糖耐量试验（OGTT）。通过免疫组织化学评估肌肉纤维毛细血管化。根据整个组的中位数，将参与者分为肌肉纤维毛细血管化相对较低（LOW）或较高（HIGH）的组（毛细血管与纤维周长交换（CFPE）指数）。根据个体OGTT结果，所有参与者均健康、非肥胖且葡萄糖耐量正常。尽管在OGTT期间各组之间未观察到血糖浓度差异，但与高肌肉纤维毛细血管化组相比，低肌肉纤维毛细血管化组餐后血浆胰岛素浓度的升高明显更大（ < 0.05）。骨骼肌纤维毛细血管化可能决定人类的胰岛素敏感性。
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