Guo B, Li J B, Wang W, Xu M, Shao Q, Liu T H
Department of Radiation Oncology, Shandong Cancer Hospital, Jinan 250117, China.
Department of Radiophysics, Shandong Cancer Hospital, Jinan 250117, China.
Zhonghua Zhong Liu Za Zhi. 2017 Apr 23;39(4):303-307. doi: 10.3760/cma.j.issn.0253-3766.2017.04.014.
To investigate the potential dosimetric benefits of four-dimensional computed tomography (4DCT) compared to three-dimensional CT (3DCT) in the planning of radiotherapy for external-beam partial breast irradiation (EB-PBI). Three-DCT and 4DCT scan sets were acquired for 20 patients who underwent EB-PBI. For each patient a conventional 3D conformal plan (3D-CRT) was generated based on end-inhalation phase (EI). The treatment plan based on the 4DCT EI phase images was copied and applied to the end-exhalation phase (EE) and 3DCT images (defined as EB-PBI(EI), EB-PBI(EE), EB-PBI(3D), respectively). The median volumes of the tumour bed based on 3DCT, EI and EE were 20.99 cm(3,) 19.28 cm(3,) and 18.78 cm(3,) respectively. The tumour bed volume based on 3DCT was significantly greater than that of EI and EE volumes (<0.05). The planning target volumes (PTV) coverage of EB-PBI(3D), EB-PBI(EI) and EB-PBI(EE) were 96.85%, 97.51%, 97.03%, respectively. The planning target volume (PTV) coverage of EB-PBI(3D) was significantly less than that of EB-PBI(EI) and EB-PBI(EE) (<0.05). The median homogeneity indexs (HI) based on 3DCT, EI and EE were 0.13, 0.13, 0.13, respectively. The median conformal indexs (CI) based on 3DCT, EI and EE were 0.68, 0.69, 0.68, respectively. The median mean doses (D(mean)) based on 3DCT, EI and EE were 36.20 Gy, 36.20 Gy, 36.22 Gy, respectively. However there were no significant differences in the homogeneity index, conformity index and the mean dose of PTV between the three treatment plans (>0.05). The EB-PBI(3D) plan resulted in the largest organs at risk dose (<0.05). There was a significant benefit when using 4DCT to plan 3D-CRT for EB-PBI with regard to reduced non-target organ exposure, and might result in poor dose coverage when the PTV is determined using 3DCT.
为了研究在调强适形放疗（IMRT）治疗鼻咽癌（NPC）的计划中，与三维适形放疗（3D-CRT）相比，调强放疗（IMRT）的潜在剂量学优势。对20例行调强适形放疗（IMRT）的鼻咽癌（NPC）患者获取三维适形放疗（3D-CRT）和调强放疗（IMRT）扫描集。对于每位患者，基于吸气末相位（EI）生成传统的三维适形计划（3D-CRT）。将基于4DCT EI相位图像的治疗计划复制并应用于呼气末相位（EE）和三维适形放疗（3D-CRT）图像（分别定义为调强适形放疗（IMRT）（EI）、调强适形放疗（IMRT）（EE）、调强适形放疗（IMRT）（3D））。基于三维适形放疗（3D-CRT）、EI和EE的瘤床中位体积分别为20.99cm³、19.28cm³和18.78cm³。基于三维适形放疗（3D-CRT）的瘤床体积显著大于EI和EE体积（<0.05）。调强适形放疗（IMRT）（3D）、调强适形放疗（IMRT）（EI）和调强适形放疗（IMRT）（EE）的计划靶区（PTV）覆盖率分别为96.85%、97.51%、97.03%。调强适形放疗（IMRT）（3D）的计划靶区（PTV）覆盖率显著低于调强适形放疗（IMRT）（EI）和调强适形放疗（IMRT）（EE）（<0.05）。基于三维适形放疗（3D-CRT）、EI和EE的中位均匀性指数（HI）分别为0.13、0.13、0.13。基于三维适形放疗（3D-CRT）、EI和EE的中位适形指数（CI）分别为0.68、0.69、0.68。基于三维适形放疗（3D-CRT）、EI和EE的中位平均剂量（D(mean)）分别为36.20Gy、36.20Gy、36.22Gy。然而，三种治疗计划之间的均匀性指数、适形指数和计划靶区（PTV）的平均剂量无显著差异（>0.05）。调强适形放疗（IMRT）（3D）计划导致危及器官剂量最大（<0.05）。在调强适形放疗（IMRT）治疗鼻咽癌（NPC）时，使用4DCT进行三维适形放疗（3D-CRT）计划在减少非靶器官照射方面有显著优势，而当使用三维适形放疗（3D-CRT）确定计划靶区（PTV）时可能导致剂量覆盖不佳。
你提供的原文与译文内容不匹配，我按照正确的原文翻译如下：
为研究在三维适形放疗（3D-CRT）治疗外照射部分乳腺照射（EB-PBI）的计划中，四维计算机断层扫描（4DCT）相较于三维CT（3DCT）的潜在剂量学优势。对20例行EB-PBI的患者获取3DCT和4DCT扫描集。为每位患者基于吸气末相位（EI）生成常规三维适形计划（3D-CRT）。将基于4DCT EI相位图像的治疗计划复制并应用于呼气末相位（EE）和3DCT图像（分别定义为EB-PBI（EI）、EB-PBI（EE）、EB-PBI（3D））。基于3DCT、EI和EE的瘤床中位体积分别为20.99cm³、19.28cm³和18.78cm³。基于3DCT的瘤床体积显著大于EI和EE体积（<0.05）。EB-PBI（3D）、EB-PBI（EI）和EB-PBI（EE）的计划靶区（PTV）覆盖率分别为96.85%、97.51%、97.03%。EB-PBI（3D）的计划靶区（PTV）覆盖率显著低于EB-PBI（EI）和EB-PBI（EE）（<0.05）。基于3DCT、EI和EE的中位均匀性指数（HI）分别为0.13、0.13、0.13。基于3DCT、EI和EE的中位适形指数（CI）分别为0.68、0.69、0.68。基于3DCT、EI和EE的中位平均剂量（D(mean)）分别为36.20Gy、36.20Gy、36.22Gy。然而，三种治疗计划之间在均匀性指数、适形指数和PTV的平均剂量方面无显著差异（>0.05）。EB-PBI（3D）计划导致危及器官剂量最大（<0.05）。在为EB-PBI进行3D-CRT计划时，使用4DCT在减少非靶器官照射方面有显著优势，而当使用3DCT确定PTV时可能导致剂量覆盖不佳。
