Plougmann Julie Isabelle, Klausen Pia, Karstensen John Gásdal, Vilmann Peter, Hasselby Jane Preuss, Hansen Carsten Palnæs, Kalaitzakis Evangelos
a Endoscopy Unit, Gastrounit , Copenhagen University Hospital Herlev, University of Copenhagen , Copenhagen , Denmark.
b Department of Pathology , Copenhagen University Hospital, Rigshospitalet , Copenhagen , Denmark.
Scand J Gastroenterol. 2017 Sep;52(9):932-940. doi: 10.1080/00365521.2017.1333628. Epub 2017 May 27.
Pancreatic cysts are increasingly diagnosed due to the widespread use of cross-sectional imaging, and some of these lesions harbor malignant potential. Mucinous cystic neoplasms and intraductal papillary mucinous neoplasms are the major premalignant cystic neoplasms of the pancreas. A variety of diagnostic tools are used to predict the malignant potential of these cysts, but specificity and sensitivity are limited. Thus, many patients undergo unnecessary operations for benign cysts. Balancing the risks of watchful waiting with those of operative management is key in managing these lesions. During the last decade, genetic changes of pancreatic cysts have been examined extensively to estimate their malignant potential. In this review, we provide an overview of the latest molecular and genetic aspects of pancreatic cysts and how they may contribute to the differential diagnosis in patients with pancreatic cystic neoplasms.
由于横断面成像技术的广泛应用，胰腺囊肿的诊断越来越多，其中一些病变具有恶变潜能。黏液性囊性肿瘤和导管内乳头状黏液性肿瘤是胰腺主要的癌前囊性肿瘤。多种诊断工具用于预测这些囊肿的恶变潜能，但特异性和敏感性有限。因此，许多患者因良性囊肿接受了不必要的手术。在处理这些病变时，平衡密切观察等待与手术治疗的风险是关键。在过去十年中，人们广泛研究了胰腺囊肿的基因变化以评估其恶变潜能。在本综述中，我们概述了胰腺囊肿最新的分子和遗传学方面，以及它们如何有助于胰腺囊性肿瘤患者的鉴别诊断。
