Lai Shih-Wei, Lin Cheng-Li, Liao Kuan-Fu
College of Medicine, China Medical University, Taichung, Taiwan.
Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan.
Int Psychogeriatr. 2017 Sep;29(9):1535-1541. doi: 10.1017/S1041610217000801. Epub 2017 May 29.
The purpose of this paper was to examine whether glaucoma could be a non-memory manifestation of Alzheimer's disease in older people.
We conducted a population-based, retrospective, case-control study to analyze the database of the Taiwan National Health Insurance Program. There were 1,351 subjects ≥65 years old with newly diagnosed Alzheimer's disease as the cases, and 5,329 subjects without any type of dementias as the controls during 2000-2011. The odds ratio (OR) and 95% confidence interval (CI) for the risk of Alzheimer's disease associated with glaucoma was estimated by the multivariable unconditional logistic regression model.
After controlling for confounders, the multivariable logistic regression model demonstrated that the adjusted OR of Alzheimer's disease was 1.50 in subjects with glaucoma (95% CI 1.19, 1.89), compared to subjects without glaucoma.
Older people with glaucoma are associated with 1.5-fold increased odds of Alzheimer's disease in Taiwan. Glaucoma may be a non-memory manifestation of Alzheimer's disease in older people. Further research is needed to confirm this issue.
本文旨在研究青光眼是否可能是老年人阿尔茨海默病的一种非记忆性表现。
我们开展了一项基于人群的回顾性病例对照研究，以分析台湾全民健康保险计划的数据库。在2000年至2011年期间，有1351名年龄≥65岁且新诊断为阿尔茨海默病的受试者作为病例，5329名无任何类型痴呆症的受试者作为对照。通过多变量无条件逻辑回归模型估计与青光眼相关的阿尔茨海默病风险的比值比（OR）和95%置信区间（CI）。
在控制混杂因素后，多变量逻辑回归模型显示，与无青光眼的受试者相比，青光眼患者患阿尔茨海默病的校正OR为1.50（95%CI为1.19, 1.89）。
在台湾，患有青光眼的老年人患阿尔茨海默病的几率增加了1.5倍。青光眼可能是老年人阿尔茨海默病的一种非记忆性表现。需要进一步研究来证实这一问题。
