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脑干和小脑海绵状血管畸形

Brainstem and cerebellar cavernous malformations.

作者信息

Atwal Gursant S, Sarris Christina E, Spetzler Robert F

机构信息

Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.

Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.

出版信息

Handb Clin Neurol. 2017;143:291-295. doi: 10.1016/B978-0-444-63640-9.00028-X.

Abstract

Cavernous malformations are vascular lesions that occur throughout the central nervous system, most commonly in the supratentorial location, with brainstem and cerebellar cavernous malformations occurring more rarely. Cavernous malformations are associated with developmental venous anomalies that occur sporadically or in familial form. Patients with a cavernous malformation can present with headaches, seizures, sensorimotor disturbances, or focal neurologic deficits based on the anatomic location of the lesion. Patients with infratentorial lesions present more commonly with a focal neurologic deficit. Cavernous malformations are increasingly discovered incidentally due to the increasing use of magnetic resonance imaging. Understanding the natural history of these lesions is essential to their management. Observation and surgical resection are both reasonable options in the treatment of patients with these lesions. The clinical presentation of the patient, the location of the lesion, and the surgical risk assessment all play critical roles in management decision-making.

摘要

海绵状血管畸形是发生于整个中枢神经系统的血管性病变,最常见于幕上部位,而脑干和小脑海绵状血管畸形则较为少见。海绵状血管畸形与发育性静脉异常相关,后者可散发或呈家族性形式出现。患有海绵状血管畸形的患者可能会根据病变的解剖位置出现头痛、癫痫发作、感觉运动障碍或局灶性神经功能缺损。幕下病变的患者更常出现局灶性神经功能缺损。由于磁共振成像的使用日益增加,海绵状血管畸形越来越多地被偶然发现。了解这些病变的自然史对其治疗至关重要。观察和手术切除都是治疗这些病变患者的合理选择。患者的临床表现、病变位置和手术风险评估在管理决策中都起着关键作用。

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