未经治疗的艾迪生病患者垂体中α-黑素细胞刺激素的产生增加。
Increased production of alpha-melanocyte-stimulating hormone in the pituitary gland of patients with untreated Addison's disease.
作者信息
Coates P J, McNicol A M, Doniach I, Rees L H
机构信息
Department of Histopathology, St. Bartholomew's Hospital, London, UK.
出版信息
Clin Endocrinol (Oxf). 1988 Oct;29(4):421-6. doi: 10.1111/j.1365-2265.1988.tb02891.x.
There is evidence that peptides related to alpha-melanocyte-stimulating hormone (alpha-MSH) are involved in regulating the zona glomerulosa of the adrenal cortex in certain species. We have investigated the amount of immunoreactive (IR)-alpha-MSH in the human pituitary gland of patients suffering from Addison's disease. We show increased numbers of cells containing demonstrable IR-alpha-MSH in the anterior lobe in these patients. Using an antiserum with specificity for the acetylated N-terminus of alpha-MSH we suggest that the major form present is desacetyl-alpha-MSH. These findings are in keeping with a role for anterior lobe derived desacetyl-alpha-MSH in the regulation of the human adrenal cortex.
有证据表明，在某些物种中，与α-黑素细胞刺激素（α-MSH）相关的肽参与调节肾上腺皮质的球状带。我们研究了患有艾迪生病的患者垂体中免疫反应性（IR）-α-MSH的含量。我们发现这些患者前叶中含有可检测到的IR-α-MSH的细胞数量增加。使用对α-MSH乙酰化N端具有特异性的抗血清，我们认为存在的主要形式是去乙酰化-α-MSH。这些发现与前叶来源的去乙酰化-α-MSH在调节人类肾上腺皮质中的作用一致。
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