Behavioral and Cellular Neuroscience, Department of Psychology, Texas A&M University, 4235 TAMU, College Station, TX, 77843, United States; Interdisciplinary Program in Neuroscience, Texas A&M Institute for Neuroscience (TAMIN), United States.
Behavioral and Cellular Neuroscience, Department of Psychology, Texas A&M University, 4235 TAMU, College Station, TX, 77843, United States; Interdisciplinary Program in Neuroscience, Texas A&M Institute for Neuroscience (TAMIN), United States.
Neurosci Biobehav Rev. 2017 Dec;83:697-712. doi: 10.1016/j.neubiorev.2017.05.017. Epub 2017 May 26.
Opioid addiction is a chronic and relapsing mental health disorder. However, only some individuals exposed to opioids, either recreationally or during the course of pain management, will develop addiction. The reasons why some individuals develop addiction and some are spared are not fully understood. Studies indicate that it is likely a combination of genetic predispositions and environmental conditions. Given the role of environmental factors in human addiction, this review examines the role of social environments and social interactions in the development of opioid addictive-like behaviors in rodent studies. To date, three major behavioral approaches have been used in these studies, namely social isolation, environmental enrichment, and social housing with a variety of cage-mates that differ in their drug administration conditions. This review highlights the importance of an individual's social network in influencing the outcomes of drug abuse and the need to further elucidate the molecular mechanisms underlying these effects. Better understanding is likely to contribute to the development of novel and more effective treatments for addiction disorders.
阿片类药物成瘾是一种慢性且易复发的心理健康障碍。然而,只有部分接触阿片类药物的个体,无论是娱乐性使用还是在疼痛管理过程中,会发展成瘾。为什么有些个体成瘾而有些个体幸免的原因尚不完全清楚。研究表明,这可能是遗传易感性和环境条件的综合作用。鉴于环境因素在人类成瘾中的作用,本综述探讨了社会环境和社会互动在啮齿动物研究中阿片类药物成瘾样行为发展中的作用。迄今为止,这些研究中使用了三种主要的行为方法,即社会隔离、环境丰富和与各种不同给药条件的笼伴一起的群居。本综述强调了个体社交网络在影响药物滥用结果方面的重要性,需要进一步阐明这些影响的分子机制。更好地理解这一点可能有助于开发新型、更有效的成瘾障碍治疗方法。