Camacho Emma, Niño-Vega Gustavo A
Department of Molecular Microbiology and Immunobiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Departamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato, GTO, Mexico.
Mediators Inflamm. 2017;2017:5313691. doi: 10.1155/2017/5313691. Epub 2017 May 2.
spp. are dimorphic fungal pathogens responsible for one of the most relevant systemic mycoses in Latin America, paracoccidioidomycosis (PCM). Their exact ecological niche remains unknown; however, they have been isolated from soil samples and armadillos (), which have been proposed as animal reservoir for these fungi. Human infection occurs by inhalation of conidia or mycelia fragments and is mostly associated with immunocompetent hosts inhabiting and/or working in endemic rural areas. In this review focusing on the pathogen perspective, we will discuss some of the microbial attributes and molecular mechanisms that enable spp. to tolerate, adapt, and ultimately avoid the host immune response, establishing infection.
某些菌种是双相真菌病原体，可引发拉丁美洲最常见的系统性真菌病之一——副球孢子菌病（PCM）。它们的确切生态位尚不清楚；然而，它们已从土壤样本和犰狳中分离出来，犰狳被认为是这些真菌的动物宿主。人类通过吸入分生孢子或菌丝体片段而感染，且大多与居住在和/或工作于地方性流行农村地区的免疫功能正常宿主有关。在本以病原体为视角的综述中，我们将讨论一些使某些菌种能够耐受、适应并最终逃避宿主免疫反应从而建立感染的微生物特性和分子机制。
