Veljković V, Metlas R
Laboratory for Multidisciplinary Research RA 180/2, Boris Kidric Institute, Beograd, Yugoslavia.
Cancer Biochem Biophys. 1988 Nov;10(2):91-106.
The information contained in the primary structure of HIV envelope gp120 determining its biological activity, was analyzed by the use of the informational spectrum method. The parameter determining the interaction between gp120 and T4 cell-surface protein was defined. On the basis of this data in the conserved region of gp120 from HTLV-III, LAVBRU and ARV-2, a nanopeptide NAKTIIVQL was identified as a potential binding domain which could be used as a component of an effective therapeutic agent or as a vaccine component.
利用信息谱方法分析了决定HIV包膜糖蛋白120（gp120）生物学活性的一级结构中所含信息。确定了决定gp120与T4细胞表面蛋白相互作用的参数。基于来自HTLV-III、LAVBRU和ARV-2的gp120保守区域的这些数据，一种九肽NAKTIIVQL被鉴定为潜在的结合结构域，可作为有效治疗剂的成分或疫苗成分。
