Peters D A, Pappas B A, Taub H, Saari M
Res Commun Chem Pathol Pharmacol. 1978 Jul;21(1):161-4.
Intraventricular 6-OHDA treatment to newborn rats produced a marked reduction in tyrosine hydroxylase activity in most brain regions at maturity which correlated moderately well with the catecholamine levels. However, those regions in which NE levels were increased did not show a corresponding increase in total tyrosine hydroxylase activity. There was a much better correlation between NE levels and the particulate form of tyrosine hydroxylase which has been suggested to be the more functionally active form of the enzyme.
对新生大鼠进行脑室内6-羟基多巴胺处理，会导致其成年后大多数脑区的酪氨酸羟化酶活性显著降低，这与儿茶酚胺水平有一定程度的相关性。然而，去甲肾上腺素（NE）水平升高的那些脑区，其酪氨酸羟化酶的总活性并未相应增加。NE水平与酪氨酸羟化酶的颗粒形式之间的相关性更好，而颗粒形式的酪氨酸羟化酶被认为是该酶更具功能活性的形式。
