硒酸盐和亚硒酸盐对缺硒大鼠血清硒浓度和谷胱甘肽过氧化物酶活性的比较作用

Comparative effect of selenate and selenite on serum selenium concentration and glutathione peroxidase activity in selenium-depleted rats.

作者信息

Korpela H

机构信息

Department of Physiology, University of Oulu, Finland.

出版信息

Ann Nutr Metab. 1988;32(5-6):347-51. doi: 10.1159/000177488.

DOI:10.1159/000177488

PMID:2855462

Abstract

The biological effect of selenate and selenite was compared in selenium-depleted rats by using both serum selenium concentration and glutathione peroxidase activity as an indicator of body selenium status. A single oral dose of selenium (125 micrograms/kg body weight) as sodium selenate or sodium selenite increased serum selenium concentration and glutathione peroxidase activity significantly (p less than 0.001). The effect of selenate and selenite on serum selenium and glutathione peroxidase activity was similar. Serum selenium concentration correlated positively with serum glutathione peroxidase activity both before (r = 0.815; p less than 0.001) and after (r = 0.800; p less than 0.001) treatment. These results indicate that the biological availability of selenate and selenite is similar.

摘要

通过使用血清硒浓度和谷胱甘肽过氧化物酶活性作为机体硒状态的指标，在缺硒大鼠中比较了硒酸盐和亚硒酸盐的生物学效应。以硒酸钠或亚硒酸钠形式单次口服给予硒（125微克/千克体重）可显著提高血清硒浓度和谷胱甘肽过氧化物酶活性（p<0.001）。硒酸盐和亚硒酸盐对血清硒和谷胱甘肽过氧化物酶活性的影响相似。治疗前（r = 0.815；p<0.001）和治疗后（r = 0.800；p<0.001）血清硒浓度均与血清谷胱甘肽过氧化物酶活性呈正相关。这些结果表明硒酸盐和亚硒酸盐的生物利用度相似。