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腹主动脉瘤监测患者心血管风险管理的多中心研究

Multi-Centre Study on Cardiovascular Risk Management on Patients Undergoing AAA Surveillance.

作者信息

Saratzis A, Dattani N, Brown A, Shalhoub J, Bosanquet D, Sidloff D, Stather P

机构信息

Department of Cardiovascular Sciences, NIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester, Leicester, UK; The Vascular and Endovascular Research Network, UK.

The Vascular and Endovascular Research Network, UK.

出版信息

Eur J Vasc Endovasc Surg. 2017 Jul;54(1):116-122. doi: 10.1016/j.ejvs.2017.04.009. Epub 2017 May 26.

Abstract

BACKGROUND

The risk of cardiovascular events and death in patients with abdominal aortic aneurysms (AAA) is high. Screening has been introduced to reduce AAA related mortality; however, after AAA diagnosis, cardiovascular modification may be as important to patient outcomes as surveillance. The aim of this study was to assess cardiovascular risk reduction in patients with small AAA.

METHODS

Institutional approval was granted for The Vascular and Endovascular Research Network (VERN) to retrospectively collect data pertaining to cardiovascular risk reduction from four tertiary vascular units in England. Patients with small AAA (January 2013-December 2015) were included. Demographic details, postcode, current medications, and smoking status were recorded using a bespoke electronic database and analysed. In a secondary analysis VERN contacted all AAA screening units in England and Wales to assess their current protocols relating to CV protection.

RESULTS

In total, 1053 patients were included (mean age 74 ± 9 years, all men). Of these, 745 patients (70.8%) had been prescribed an antiplatelet agent and 787 (74.7%) a statin. Overall, only 666 patients (63.2%) were prescribed both a statin and antiplatelet. Two hundred and sixty eight patients (32.1%) were current smokers and the proportion of patients who continued to smoke decreased with age. Overall, only 401 patients (48.1%) were prescribed a statin, antiplatelet, and had stopped smoking. In the secondary analysis 38 AAA screening units (84% national coverage) replied. Thirty-one units (82%) suggest changes to the patient's prescription; however, none monitor compliance with these recommendations or assess whether the general practitioner has been made aware of the AAA diagnosis or prescription advice.

CONCLUSION

Many patients with small AAA are not prescribed an antiplatelet/statin, and still smoke cigarettes, and therefore remain at high risk of cardiovascular morbidity and mortality. National guidance to ensure this high risk group of patients is adequately protected from poor cardiovascular outcomes is lacking.

摘要

背景

腹主动脉瘤(AAA)患者发生心血管事件和死亡的风险很高。已引入筛查以降低与AAA相关的死亡率;然而,在AAA诊断后,心血管疾病的改善对于患者预后可能与监测同样重要。本研究的目的是评估小型AAA患者的心血管风险降低情况。

方法

血管与血管内研究网络(VERN)获得机构批准,以回顾性收集来自英格兰四个三级血管单位的与心血管风险降低相关的数据。纳入小型AAA患者(2013年1月至2015年12月)。使用定制的电子数据库记录并分析人口统计学细节、邮政编码、当前用药情况和吸烟状况。在二次分析中,VERN联系了英格兰和威尔士的所有AAA筛查单位,以评估其当前与心血管保护相关的方案。

结果

共纳入1053例患者(平均年龄74±9岁,均为男性)。其中,745例患者(70.8%)被开具了抗血小板药物,787例(74.7%)被开具了他汀类药物。总体而言,只有666例患者(63.2%)同时被开具了他汀类药物和抗血小板药物。268例患者(32.1%)为当前吸烟者,继续吸烟的患者比例随年龄下降。总体而言,只有401例患者(48.1%)被开具了他汀类药物、抗血小板药物且已戒烟。在二次分析中,38个AAA筛查单位(全国覆盖率84%)回复。31个单位(82%)建议更改患者的处方;然而,没有一个单位监测对这些建议的依从性,也没有评估全科医生是否已了解AAA诊断或处方建议。

结论

许多小型AAA患者未被开具抗血小板药物/他汀类药物,仍在吸烟,因此仍然面临心血管发病和死亡的高风险。缺乏确保这一高危患者群体充分预防不良心血管结局的国家指南。

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