Silva Daliana Caldas, Gonçalves Ana Katherine, Cobucci Ricardo Ney, Mendonça Roberta Cecília, Lima Paulo Henrique, Cavalcanti Geraldo
Health Science Post Graduation Program, Universidade Federal do Rio Grande do Norte - UFRN, Natal, RN, Brazil.
Health Science Post Graduation Program, Universidade Federal do Rio Grande do Norte - UFRN, Natal, RN, Brazil.
Pathol Res Pract. 2017 Jul;213(7):723-729. doi: 10.1016/j.prp.2017.03.003. Epub 2017 Mar 14.
This study evaluated the immunohistochemical (IHC) expression of p16, p53 and Ki-67 in precancerous lesions and in cervical cancer (CC). Identification and review of publications assessing IHC expression in cervical intraepithelial neoplasia (CIN) and CC until February 15, 2017. Systematic review of studies in women with and without cervical lesions in order to evaluate whether there is overexpression of these biomarkers. A total of 28 publications met the criteria which included 6005 patients. The analysis showed that there is higher IHC expression of these biomarkers associated with the more severe lesions. Nineteen out of 22 evaluated studies have shown that there is a higher p16 expression in more severe lesions (CC), while in p53 expression only 4 out of the 9 studies showed a higher expression among more severe cases. Regarding the Ki-67 expression, it was observed that 9 out of 14 studies showed higher expression in more severe lesions. A complete absence of or just minimal IHC expression was observed in the normal cervical epithelium, whilst a significant increase in the expression of these biomarkers was detected according to the severity of lesions. Results suggest that these biomarkers can be considered useful tools for discriminating between the stages of the progressive cervical disease.
本研究评估了p16、p53和Ki-67在癌前病变和宫颈癌（CC）中的免疫组化（IHC）表达。检索并回顾了截至2017年2月15日评估宫颈上皮内瘤变（CIN）和CC中IHC表达的文献。对有和没有宫颈病变的女性进行系统研究，以评估这些生物标志物是否存在过表达。共有28篇文献符合标准，包括6005例患者。分析表明，这些生物标志物的IHC表达越高，病变越严重。在22项评估研究中，有19项表明在更严重的病变（CC）中p16表达更高，而在p53表达方面，9项研究中只有4项表明在更严重的病例中表达更高。关于Ki-67表达，观察到14项研究中有9项表明在更严重的病变中表达更高。在正常宫颈上皮中观察到完全没有或仅有极少的IHC表达，而根据病变的严重程度检测到这些生物标志物的表达显著增加。结果表明，这些生物标志物可被视为区分宫颈疾病进展阶段的有用工具。
