Philouze Pierre, Péron Julien, Poupart Marc, Pujo Kevin, Buiret Guillaume, Céruse Philippe
Department of Head and Neck Surgery, Hospital de la Croix Rousse Hospices Civils de Lyon, Lyon, France.
Biostatistics Department, CHU Lyon Sud, Hospices Civils de Lyon, Pierre, Benité, France.
Head Neck. 2017 Sep;39(9):1744-1750. doi: 10.1002/hed.24827. Epub 2017 May 30.
In the case of a locoregional recurrence of oropharyngeal squamous cell carcinoma, the curative standard of care is surgery. Our main purpose of this study was to determine the preoperative prognostic factors that would allow us to select the patients on whom we could expect good results with salvage surgery.
We conducted a monocentric retrospective study from 2005 to 2013. It included all patients treated for a recurrence of oropharyngeal squamous cell carcinoma with surgery. Their initial treatment included radiotherapy.
Fifty-two patients were included. Poor prognostic factors for survival were the cT status (P = .0039) and local recurrences versus secondary localizations in irradiated areas (P = .016) and a relapse less than a year after the end of the initial treatment (P = .050). Recurrence-free survival was 19% at 5 years. Twenty-nine percent of patients presented local complications, which were mainly fistulas and hemorrhaging at the surgical site.
According to the high morbimortality, it is important to carefully select the right patients for surgery.
对于口咽鳞状细胞癌局部区域复发的情况，标准的治疗方法是手术。本研究的主要目的是确定术前的预后因素，以便我们能够选择那些有望通过挽救性手术获得良好效果的患者。
我们进行了一项2005年至2013年的单中心回顾性研究。研究纳入了所有接受口咽鳞状细胞癌复发手术治疗的患者。他们的初始治疗包括放疗。
共纳入52例患者。生存的不良预后因素包括cT状态（P = 0.0039）、局部复发与放疗区域的二次局部病变（P = 0.016）以及初始治疗结束后不到一年出现复发（P = 0.050）。5年无复发生存率为19%。29%的患者出现局部并发症，主要是手术部位的瘘管和出血。
鉴于高病残率和死亡率，仔细选择合适的手术患者非常重要。
