Yan Qingguang, Jin Gui, Ma Ke, Qin Mingxin, Zhuang Wei, Sun Jian
College of Biomedical Engineering, Third Military Medical University, Chongqing, 400030, China.
Biomed Eng Online. 2017 May 30;16(1):63. doi: 10.1186/s12938-017-0354-7.
The major therapy for ischemic stroke is thrombolytic treatment, but severe consequences occur when this method is used to treat hemorrhagic stroke. Currently, computed tomography and magnetic resonance imaging are used to differentiate between two types of stroke, but these two methods are ineffective for pre-hospital care.
We developed a new brain diagnostic device for rabbits based on electromagnetic induction to non-invasively differentiate two types of stroke. The device includes two coils and a phase difference measurement system that detects the magnetic inductive phase shift (MIPS) value to reflect the tissue's condition. The hemorrhage model was established through the injection of autologous blood into the internal capsule of a rabbit's brain. Ischemia was induced in the brain of a rabbit by bilateral carotid artery occlusion. Two types of animal models were measured with our device.
The MIPS value gradually decreased with increasing injected blood and increased with ischemia time. The MIPS changes induced by the two types of strokes were exact opposites, and the absolute values of MIPS variation in the hemorrhagic and the ischemic groups were significantly larger than those of the normal control group (P < 0.05).
The tested technique can differentiate ischemic stroke from hemorrhagic stroke on rabbit brain in a non-invasive, continuous, and bulk monitoring manner by using a simple and inexpensive apparatus.
缺血性中风的主要治疗方法是溶栓治疗，但用这种方法治疗出血性中风会产生严重后果。目前，计算机断层扫描和磁共振成像用于区分两种类型的中风，但这两种方法在院前护理中无效。
我们基于电磁感应开发了一种用于兔子的新型脑诊断设备，以无创区分两种类型的中风。该设备包括两个线圈和一个相位差测量系统，该系统检测磁感应相移（MIPS）值以反映组织状况。通过将自体血注入兔子脑内囊来建立出血模型。通过双侧颈动脉闭塞在兔子脑中诱导缺血。用我们的设备测量两种动物模型。
MIPS值随着注入血液量的增加而逐渐降低，并随着缺血时间的增加而升高。两种类型中风引起的MIPS变化正好相反，出血组和缺血组MIPS变化的绝对值明显大于正常对照组（P<0.05）。
所测试的技术可以通过使用简单且廉价的设备，以无创、连续和整体监测的方式区分兔子脑中的缺血性中风和出血性中风。
