Ding Xu-Dong, Zhong Jing, Liu Yan-Ping, Chen Hua-Xian
Dept. of Rehabilitation Medicine, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei, China.
Dept. of Ultrasound Imaging, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei, China.
Iran J Public Health. 2017 May;46(5):608-611.
We aimed to study the curative effects of botulinum A toxin (BTX-A) on the treatment of post-herpetic neuralgia (PNH).
We enrolled 58 PNH patients and treated them with hypodermic injection of BTX-A in Xiangyang No.1 People's Hospital, Hubei University of Medicine, Hubei, China. We measured and compared the Visual Analog Score (VAS), Neuropathy Pain Scale (NPS), Quality of Life Scale (SF-36) score, PNH seizure severity degree, seizure duration, frequency of attack and the use of painkillers before and after treatment. We used SPSS13 software package for statistical analysis. Values were expressed by mean± standard deviation. <0.05 indicated a significant difference and P<0.01 indicated an obvious significant difference.
Attack frequency, attack duration and attack severity were all significantly lower after treatment (<0.01). The use of painkillers reduced after treatment (<0.01) and we observed very few adverse reactions associated with BTX-A injection.
The use of BTX-A for treating post-herpetic neuralgia produced very promising results with very few adverse reactions. BTX-A can be considered as a valid approach in the treatment of PNH, especially in patients that do not respond well to painkillers.
我们旨在研究A型肉毒毒素（BTX-A）治疗带状疱疹后神经痛（PNH）的疗效。
我们纳入了58例PNH患者，并在中国湖北省湖北医药学院附属襄阳市第一人民医院对他们进行皮下注射BTX-A治疗。我们测量并比较了治疗前后的视觉模拟评分（VAS）、神经病理性疼痛量表（NPS）、生活质量量表（SF-36）评分、PNH发作严重程度、发作持续时间、发作频率以及止痛药的使用情况。我们使用SPSS13软件包进行统计分析。数值以均数±标准差表示。P<0.05表示差异有统计学意义，P<0.01表示差异有显著统计学意义。
治疗后发作频率、发作持续时间和发作严重程度均显著降低（P<0.01）。治疗后止痛药的使用减少（P<0.01），并且我们观察到与BTX-A注射相关的不良反应极少。
使用BTX-A治疗带状疱疹后神经痛取得了非常有前景的结果，不良反应极少。BTX-A可被视为治疗PNH的一种有效方法，尤其是对止痛药反应不佳的患者。
