Meybohm Patrick, Müller Markus M, Zacharowski Kai
Anasthesiol Intensivmed Notfallmed Schmerzther. 2017 May;52(5):326-340. doi: 10.1055/s-0042-108925. Epub 2017 May 22.
Patient Blood Management (PBM) focusses on anemia management, the minimization of (unnecessary) iatrogenic blood loss and the exhaustion of natural tolerance to anemia with rational use of red blood cell transfusion. The focus of the current review article is now the preoperative phase with the following PBM components: management of anemia, pre-transfusion analytics and management of anticoagulants. Preoperative anemia is an independent risk factor for increased perioperative morbidity and mortality. In elective surgery, the causes of anemia should be diagnosed prior to surgery as early as possible, and if indicated, a specific treatment for treatable causes should be initiated. Preoperative pre-transfusion analytics should be performed by a step-wise approach depending on the transfusion probability (and the baseline hemoglobin) and current in-house data. Management of (oral) anticoagulants needs to consider an individual risk stratification for bleeding and thromboembolic events, should be initiated in the preoperative phase, and should specify whether the anticoagulant needs to be continued, stopped or bridged. Long-term success of the preoperative PBM program can only be guaranteed with clearly defined responsibilities in the preoperative PBM team, communication and training of all those involved in the process of care.
患者血液管理(PBM)侧重于贫血管理、尽量减少(不必要的)医源性失血以及通过合理使用红细胞输血避免对贫血的自然耐受性耗竭。当前这篇综述文章的重点是术前阶段,包括以下PBM组成部分:贫血管理、输血前分析和抗凝管理。术前贫血是围手术期发病率和死亡率增加的独立危险因素。在择期手术中,应尽早在手术前诊断贫血的原因,如有必要,应对可治疗的病因启动特定治疗。术前输血前分析应根据输血可能性(和基线血红蛋白)以及当前的内部数据采用逐步方法进行。(口服)抗凝管理需要考虑出血和血栓栓塞事件的个体风险分层,应在术前阶段启动,并应明确抗凝剂是否需要继续、停用或桥接。术前PBM计划的长期成功只有在术前PBM团队明确职责、对护理过程中所有相关人员进行沟通和培训的情况下才能得到保证。