a Ophthalmology , Oregon Health & Science University , Portland , Oregon , USA.
b Centre for Eye Research Australia , University of Melbourne , Melbourne , Australia.
Ocul Immunol Inflamm. 2018;26(6):900-909. doi: 10.1080/09273948.2017.1298818. Epub 2017 May 31.
Keratic precipitates (KP) are a common feature of uveitis. We prospectively examined KP with the Heidelberg Retinal Tomograph II confocal laser scanning microscope and Rostock Corneal Module (HRT-RCM) to explore their diagnostic implications.
Prospective, observational, multicenter study. HRT-RCM images were classified by two masked observers.
120 scans on 120 eyes from 110 subjects were included. The majority (N = 93) had non-infectious uveitis. Sixty eyes had active disease at scanning. Eight KP morphologies were defined. Agreement between the two masked graders was high (Kappa value across all categories = 0.81). Cluster and nodular KP were associated with active infectious uveitis (p < 0.01): patients with cluster KP (odds ratio [OR] = 3.03, 95% confidence interval [CI]: 1.43, 6.45) and nodular KP (OR = 3.89, 95% CI: 1.42, 10.65) were more likely to have infectious uveitis than those without.
Laser confocal microscopy of KP may have a role in determining between infectious and non-infectious uveitis.
角膜后沉着物（KP）是葡萄膜炎的常见特征。我们前瞻性地使用海德堡视网膜断层扫描仪 II 共焦激光扫描显微镜和 Rostock 角膜模块（HRT-RCM）检查 KP，以探讨其诊断意义。
前瞻性、观察性、多中心研究。两名有经验的观察者对 HRT-RCM 图像进行分类。
共纳入 110 例患者 120 只眼的 120 次扫描。大多数（N=93）为非感染性葡萄膜炎。扫描时 60 只眼处于活动期。共定义了 8 种 KP 形态。两名有经验的观察者之间的一致性很高（所有分类的 Kappa 值=0.81）。簇状和结节状 KP 与活动性感染性葡萄膜炎相关（p<0.01）：簇状 KP（比值比 [OR] = 3.03，95%置信区间 [CI]：1.43，6.45）和结节状 KP（OR = 3.89，95% CI：1.42，10.65）患者更有可能患有感染性葡萄膜炎。
KP 的激光共焦显微镜检查可能有助于鉴别感染性和非感染性葡萄膜炎。
