序列多肽（丙氨酸-酪氨酸-谷氨酸-甘氨酸）n、（丙氨酸-谷氨酸-酪氨酸-甘氨酸）n、（谷氨酸-丙氨酸-酪氨酸-甘氨酸）n和（谷氨酸-酪氨酸-丙氨酸-甘氨酸）n在小鼠中的免疫原性及其与主要组织相容性复合体的联系。
Immunogenicity in mice of the sequential polypeptides (Ala-Tyr-Glu-Gly)n, (Ala-Glu-Tyr-Gly)n, (Glu-Ala-Tyr-Gly)n and (Glu-Tyr-Ala-Gly)n and their linkage with the major histocompatibility complex.
作者信息
Maurer P H, Lai C H, Zeiger A R, Turchin H
机构信息
Department of Biochemistry, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pa.
出版信息
Exp Clin Immunogenet. 1986;3(4):201-7.
The immunogenicity of the four sequential polymers of alpha-L-amino acids referred to below was studied in inbred strains of mice. The responses were linked to the H-2 haplotype, and the Ir genes controlling the responses were mapped to the IA region. The responses were restricted to two haplotypes as follows: (Ala-Tyr-Glu-Gly)n and (Ala-Glu-Tyr-Gly)n - H-2k; (Glu-Ala-Tyr-Gly)n - H-2b; (Glu-Tyr-Ala-Gly)n - H-2k and b. The absence of reciprocal crossreactions among all of these polymers, plus the sequential polymers (Tyr-Ala-Glu-Gly)n and (Tyr-Glu-Ala-Gly)n at both the antibody and T-cell levels, indicated that each of these six polymers was indeed structurally unique.
对下述四种α-L-氨基酸的连续聚合物在近交系小鼠中的免疫原性进行了研究。这些反应与H-2单倍型相关，控制这些反应的Ir基因被定位到IA区域。反应限于以下两种单倍型：(丙氨酸-酪氨酸-谷氨酸-甘氨酸)n和(丙氨酸-谷氨酸-酪氨酸-甘氨酸)n - H-2k；(谷氨酸-丙氨酸-酪氨酸-甘氨酸)n - H-2b；(谷氨酸-酪氨酸-丙氨酸-甘氨酸)n - H-2k和b。所有这些聚合物之间以及在抗体和T细胞水平上的连续聚合物(酪氨酸-丙氨酸-谷氨酸-甘氨酸)n和(酪氨酸-谷氨酸-丙氨酸-甘氨酸)n均不存在交叉反应，这表明这六种聚合物中的每一种在结构上确实是独特的。
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