Koolen M J, Buchmeier M J
Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, California 92037.
Microbiol Sci. 1986 Mar;3(3):68-73.
Several lines of evidence suggest that viruses may be aetiologically related to human demyelinating disorders, but no clear causal relationships have been established. In an effort to understand the pathogenesis of virus-induced CNS disease, animal model systems have been employed. Recent results indicate that mutational changes in viral surface components may profoundly affect the course and outcome of disease.
多项证据表明，病毒可能在病因上与人类脱髓鞘疾病相关，但尚未确立明确的因果关系。为了了解病毒诱导的中枢神经系统疾病的发病机制，人们采用了动物模型系统。最近的结果表明，病毒表面成分的突变可能会深刻影响疾病的进程和结果。
