Snyder Lee R G, Hayes Jack P, Chappell Mark A
Department of Biology, University of California, Riverside, CA, 92521.
White Mountain Research Station, Bishop, CA, 93514.
Evolution. 1988 Jul;42(4):689-697. doi: 10.1111/j.1558-5646.1988.tb02487.x.
In deer mouse (Peromyscus maniculatus) populations in the western United States, alpha-globin haplotype frequency, beta-globin haplotype frequency, and base-line blood oxygen affinity (measured after acclimation to low altitude) show strong correlations with native altitude. The correlations improve when an average regional altitude is substituted for the local altitude at collection sites. This substitution roughly compensates for the effects of gene exchange between populations in areas of highly variable topography. When subspecific effects are removed with covariate analyses a significant (P < 0.05) relationship remains only for alpha-globin haplotype frequency and altitude. Thus, alpha-globin haplotype frequency, beta-globin haplotype frequency, and base-line blood oxygen affinity may be explained by either subspecific or altitudinal effects, but subspecific effects explain a larger proportion of the variance. Part of the subspecific effect may be attributable to an underlying relationship of subspecies with altitude. The analyses for the alpha-globins in conjunction with other data on the effects of alpha-globins on blood oxygen affinity and whole-animal physiological performance are consistent with the hypothesis that the frequency of the alpha-globins evolved in response to selection resulting from the stress of high-altitude hypoxia.
在美国西部的鹿鼠（白足鼠）种群中，α-珠蛋白单倍型频率、β-珠蛋白单倍型频率以及基线血氧亲和力（在适应低海拔后测量）与原生海拔高度呈现出强烈的相关性。当用区域平均海拔替代采集地点的当地海拔时，相关性有所改善。这种替代大致补偿了地形高度变化区域中种群间基因交换的影响。当通过协变量分析去除亚种效应后，仅α-珠蛋白单倍型频率与海拔之间仍存在显著（P < 0.05）关系。因此，α-珠蛋白单倍型频率、β-珠蛋白单倍型频率和基线血氧亲和力可能由亚种效应或海拔效应来解释，但亚种效应解释了更大比例的方差。部分亚种效应可能归因于亚种与海拔之间的潜在关系。对α-珠蛋白的分析以及关于α-珠蛋白对血氧亲和力和全动物生理性能影响的其他数据，与α-珠蛋白频率因高海拔低氧应激导致的选择而进化的假设一致。
