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胶质瘤治疗的最新进展 - 综合脑肿瘤中心

Recent Advances in the Treatment of Gliomas - Comprehensive Brain Tumor Center.

作者信息

Toms Steven A, Tapinos Nikolaos

机构信息

Vice Chair, Department of Neurosurgery, Warren Alpert Medical School of Brown University; Director, Brain Tumor Program; Lifespan Health System, Providence, RI.

Director of Molecular Neuroscience & Neuro-Oncology, Department of Neurosurgery, Warren Alpert Medical School of Brown University; Lifespan Health System, Providence, RI.

出版信息

R I Med J (2013). 2017 Jun 1;100(6):43-46.

Abstract

Gliomas are a class of primary brain tumors arising from the supporting structures of the brain, the astrocytes and oligodendrocytes, which range from benign lesions to its most malignant form, the glioblastoma. Treatment for these lesions includes maximal surgical resection, radiotherapy, and chemotherapy. Recently, novel therapies such as immune modulatory therapies and electrical field treatment of the most malignant form, the glioblastoma, have shown promise in improving survival. We will review recent advances in clinical trials, explore the role of multimodal care in brain tumor therapy, as well as explore advances in molecular biology and nanotechnology which offer new hope for treatment of this class of disease. [Full article available at http://rimed.org/rimedicaljournal-2017-06.asp].

摘要

胶质瘤是一类起源于脑支持结构(星形胶质细胞和少突胶质细胞)的原发性脑肿瘤,其范围从良性病变到最恶性的形式——胶质母细胞瘤。这些病变的治疗方法包括最大程度的手术切除、放疗和化疗。最近,诸如免疫调节疗法和针对最恶性形式的胶质母细胞瘤的电场治疗等新疗法在提高生存率方面显示出了前景。我们将回顾临床试验的最新进展,探讨多模式治疗在脑肿瘤治疗中的作用,以及探索分子生物学和纳米技术的进展,这些进展为这类疾病的治疗带来了新希望。[全文可在http://rimed.org/rimedicaljournal-2017-06.asp获取]

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