Li Zhihong, Wang Qihong, Mi Wenxin, Han Mei, Gao Fei, Niu Guangyan, Ma Yindong
Department of Burns Surgery, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, P.R. China.
Exp Ther Med. 2017 May;13(5):2211-2216. doi: 10.3892/etm.2017.4266. Epub 2017 Mar 27.
The effects of negative pressure wound therapy (NPWT) combined with microplasma on treating wounds of ulcer, and blood perfusion of wound-healing of interface, angiogenesis and the expressions of heat shock protein 90 (HSP90) were explored. We selected continuously 64 patients with wounds of ulcer. The patients were divided into the conventional treatment group (just medical foam dressing and 1% silver sulfadiazine cream for dressing changes) (n=20 cases), the NPWT group (n=22 cases) and the combination group (NPWT combined with microplasma) (n=22 cases), and compared the effects. It was found that in the 7 and 14 day combination group, maturity of granulation tissues and growth degree of epithelium were significantly higher than those in other two groups, and the areas of ulcer reduced significantly, the healing rate increased significantly (P<0.05). In the 7 and 14 day combination group, blood perfusion of wounds and density of new vessels were significantly higher than the other two groups (P<0.05). In the 7 and 14 day combination group, the expression of HSP90 was significantly higher than the other two groups (P<0.05). In conclusion, NPWT combined with microplasma can improve the healing of woulds of ulcers, and it is related to the upregulated expression of HSP90.
探讨负压伤口治疗（NPWT）联合微等离子体对溃疡创面的治疗效果，以及创面愈合界面的血液灌注、血管生成和热休克蛋白90（HSP90）的表达情况。我们连续选取64例溃疡创面患者。将患者分为传统治疗组（仅用医用泡沫敷料和1%磺胺嘧啶银乳膏换药）（n = 20例）、NPWT组（n = 22例）和联合组（NPWT联合微等离子体）（n = 22例），并比较疗效。结果发现，在第7天和第14天，联合组的肉芽组织成熟度和上皮生长程度明显高于其他两组，溃疡面积明显缩小，愈合率显著提高（P < 0.05）。在第7天和第14天，联合组创面的血液灌注和新生血管密度明显高于其他两组（P < 0.05）。在第7天和第14天，联合组HSP90的表达明显高于其他两组（P < 0.05）。综上所述，NPWT联合微等离子体可促进溃疡创面愈合，且与HSP90表达上调有关。
