Colombo Luca, Martini Carlotta, Bersanini Chiara, Izzo Francesca, Villafañe Jorge H, Berjano Pedro, Lamartina Claudio
Galeazzi Orthopedic Institute IRCCS, Milan, Italy.
Vittore Buzzi Hospital, Milan, Italy.
J Neurosurg Sci. 2020 Jun;64(3):253-257. doi: 10.23736/S0390-5616.17.04052-8. Epub 2017 May 31.
The aim of this study was to determine the effects of magnetically controlled growing rods surgery (MCGRS) of the scoliosis on pulmonary function in children with neuromuscular scoliosis.
Seven patients, 85.7% female (mean±SD age: 6.7±1.2 years), with neuromuscular scoliosis (4 SMA II, 2 congenital myopathies and 1 VACTER syndrome), received MCGRS of the spine in the thoraco-lumbar area. The outcome measures were clinical features and pulmonary function (forced vital capacity [FVC] and forced expiratory volume in 1st second [FEV1], were collected. All measures were collected at pre-, post-intervention and follow-up (short-term [0-6 months], mid-term [7-12 months], and long-term [13-24 months]).
MCGRS reduced Cobb angle after intervention in 100% in subjects and this result was maintained at 24-month follow-up (all, P=0.001). There was no significant difference in FVC or FEV1 between preoperative and each postoperative period, (P>0.05). Analyses of the correlation coefficients indicated no significant associations between changes in pulmonary function and scoliosis.
The current study found that MCGRS addressed to the scoliosis maintained pulmonary function during long-term follow-up; However, pulmonary function was not associated with scoiosis in children with neuromuscular scoliosis.
本研究旨在确定脊柱侧弯的磁控生长棒手术（MCGRS）对神经肌肉型脊柱侧弯儿童肺功能的影响。
7例神经肌肉型脊柱侧弯患者（4例脊髓性肌萎缩症II型、2例先天性肌病和1例VACTER综合征），女性占85.7%（平均±标准差年龄：6.7±1.2岁），接受了胸腰段脊柱的MCGRS。观察指标为临床特征和肺功能（收集用力肺活量[FVC]和第1秒用力呼气量[FEV1]）。所有指标均在干预前、干预后及随访时（短期[0 - 6个月]、中期[7 - 12个月]和长期[13 - 24个月]）收集。
MCGRS使受试者干预后Cobb角减小100%，且该结果在24个月随访时保持（所有，P = 0.001）。术前与术后各时期的FVC或FEV1无显著差异（P>0.05）。相关系数分析表明肺功能变化与脊柱侧弯之间无显著关联。
本研究发现，针对脊柱侧弯的MCGRS在长期随访中维持了肺功能；然而，神经肌肉型脊柱侧弯儿童的肺功能与脊柱侧弯无关。
