Pereira E A C, Oxenham M, Lam K S
University of London, London SW17 0RE, UK.
King's College London, London, UK.
Bone Joint J. 2017 Jun;99-B(6):829-833. doi: 10.1302/0301-620X.99B6.BJJ-2016-1159.R1.
In the United Kingdom, lower incidences of intraspinal abnormalities in patients with early onset idiopathic scoliosis have been observed than in studies in other countries. We aimed to determine the rates of these abnormalities in United Kingdom patients diagnosed with idiopathic scoliosis before the age of 11 years.
This retrospective study of patients attending an urban scoliosis clinic identified 71 patients satisfying a criteria of: clinical diagnosis of idiopathic scoliosis; age of onset ten years and 11 months or less; MRI screening for intraspinal abnormalities. United Kingdom census data combined with patient referral data was used to calculate incidence.
Mean age at diagnosis was six years with 39 right-sided and 32 left-sided curves. Four patients (5.6%) were found to have intraspinal abnormalities on MRI. These consisted of: two combined Arnold-Chiari type 1 malformations with syrinx; one syrinx with a low lying conus; and one isolated syrinx. Overall annual incidence of early onset idiopathic scoliosis was one out of 182 000 (0.0006%).
This study reports the lowest rates to date of intraspinal anomalies in patients with early onset idiopathic scoliosis, adding to knowledge regarding current incidences of these abnormalities as well as any geographical variation in the nature of the disease. Cite this article: 2017;99-B:829-33.
在英国，与其他国家的研究相比，早发性特发性脊柱侧凸患者的脊柱内异常发生率较低。我们旨在确定在英国11岁之前被诊断为特发性脊柱侧凸的患者中这些异常的发生率。
这项对一家城市脊柱侧凸诊所就诊患者的回顾性研究确定了71名符合以下标准的患者：特发性脊柱侧凸的临床诊断；发病年龄为10岁11个月或更小；进行脊柱内异常的MRI筛查。结合英国人口普查数据和患者转诊数据来计算发病率。
诊断时的平均年龄为6岁，有39个右侧弯曲和32个左侧弯曲。4名患者（5.6%）在MRI上被发现有脊柱内异常。这些异常包括：2例合并1型阿诺德-奇亚里畸形和脊髓空洞症；1例脊髓空洞症伴低位圆锥；1例孤立性脊髓空洞症。早发性特发性脊柱侧凸的总体年发病率为182000分之一（0.0006%）。
本研究报告了迄今为止早发性特发性脊柱侧凸患者脊柱内异常的最低发生率，增加了关于这些异常当前发生率以及疾病性质的任何地理差异的知识。引用本文：2017；99-B：829-33。
