França Carolina N, Izar Maria C O, Hortêncio Marinella N S, do Amaral Jônatas B, Ferreira Carlos E S, Tuleta Izabela D, Fonseca Francisco A H
Santo Amaro University-Health Sciences Post Graduation, São Paulo - SP, Brazil
Federal University of Sao Paulo, Department of Medicine, Cardiology Division, São Paulo - SP, Brazil.
Clin Sci (Lond). 2017 Jun 1;131(12):1215-1224. doi: 10.1042/CS20170009.
Monocytes circulate in the blood and migrate to inflammatory tissues, but their functions can be either detrimental or beneficial, depending on their phenotypes. In humans, classical monocytes are inflammatory cluster of differentiation (CD)14CD16CCR2 cells originated from the bone marrow or spleen reservoirs and comprise ≥92% of monocytes. Intermediate monocytes (CD14CD16CCR2) are involved in the production of anti-inflammatory cytokines [such as interleukin (IL)-10], reactive oxygen species (ROS), and proinflammatory mediators [such as tumor necrosis factor-α (TNF-α) and IL-1β). Nonclassical monocytes (CD14CD16CCR2) are patrolling cells involved in tissue repair and debris removal from the vasculature. Many studies in both humans and animals have shown the importance of monocyte chemoattractant protein-1 (MCP-1) and its receptor [chemokine receptor of MCP-1 (CCR2)] in pathologies, such as atherosclerosis and myocardial infarction (MI). This review presents the importance of these monocyte subsets in cardiovascular diseases (CVDs), and sheds light on new strategies for the blocking of the MCP-1/CCR2 axis as a therapeutic goal for treating vascular disorders.
单核细胞在血液中循环并迁移至炎症组织，但其功能取决于其表型，可能有害也可能有益。在人类中，经典单核细胞是起源于骨髓或脾脏储存库的炎症性分化簇（CD）14⁺CD16⁻CCR2⁺细胞，占单核细胞的≥92%。中间单核细胞（CD14⁺CD16⁺CCR2⁺）参与抗炎细胞因子[如白细胞介素（IL）-10]、活性氧（ROS）和促炎介质[如肿瘤坏死因子-α（TNF-α）和IL-1β]的产生。非经典单核细胞（CD14⁻CD16⁺CCR2⁺）是参与组织修复和从脉管系统清除碎片的巡逻细胞。许多人和动物研究表明单核细胞趋化蛋白-1（MCP-1）及其受体[MCP-1的趋化因子受体（CCR2）]在动脉粥样硬化和心肌梗死（MI）等病理状况中的重要性。本综述阐述了这些单核细胞亚群在心血管疾病（CVD）中的重要性，并阐明了阻断MCP-1/CCR2轴作为治疗血管疾病的治疗目标的新策略。
