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环丙沙星在模拟胃肠道液体中与蒙脱石存在时与氧化石墨烯和还原氧化石墨烯的相互作用过程。

Interaction processes of ciprofloxacin with graphene oxide and reduced graphene oxide in the presence of montmorillonite in simulated gastrointestinal fluids.

机构信息

School of Energy & Environmental Engineering, University of Science and Technology Beijing, 30 Xueyuan Road, 100083, Beijing, China.

Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants, University of Science and Technology Beijing, 30 Xueyuan Road, 100083, Beijing, China.

出版信息

Sci Rep. 2017 May 31;7(1):2588. doi: 10.1038/s41598-017-02620-4.

DOI:10.1038/s41598-017-02620-4
PMID:28566735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5451422/
Abstract

This study investigated the interaction processes of ciprofloxacin (CIP) with graphene oxide (GO) and reduced GO (rGO) in presence of montmorillonite (Mont) in simulated gastrointestinal fluids. The order of CIP adsorption affinity was rGO+Mont > GO+Mont > rGO+Mont+pepsin > rGO > GO+Mont+pepsin > Mont > Mont+pepsin > GO > rGO+pepsin > GO+pepsin in simulated gastric fluid. Mont enhanced the adsorption of CIP on GO and rGO due to hydrated Si species coating on GO and rGO in the simulated gastric fluid. Meanwhile, π-π interaction between CIP and graphene caused the great shift of two cyclopropyl CH and one cyclopropyl in CIP molecules. And GO, rGO, and Mont interacted mainly with CIP by COOH groups. CIP and pepsin molecules could intercalate and increase the basal spacing of Mont as well. After the various interaction systems of adsorbent-adsorbate transferring to the simulated intestinal fluid, CIP was continuously adsorbed by GO and rGO. In addition, adsorbed CIP was released from Mont into the solution through electrostatic repulsion. The decrease ratio of CIP was the lowest in the GO/rGO+Mont+pepsin systems. Therefore, the mixture of Mont and GO/rGO decreased the CIP concentration in gastrointestinal fluid to weaken further antibiotic activity of CIP.

摘要

本研究考察了在模拟胃肠道溶液中，环丙沙星（CIP）与氧化石墨烯（GO）和还原氧化石墨烯（rGO）与蒙脱石（Mont）之间的相互作用过程。在模拟胃液中，CIP 的吸附亲和力顺序为 rGO+Mont>GO+Mont>rGO+Mont+胃蛋白酶>rGO>GO+Mont+胃蛋白酶>Mont>Mont+胃蛋白酶>GO>rGO+胃蛋白酶>GO+胃蛋白酶。由于在模拟胃液中，水化 Si 物种覆盖在 GO 和 rGO 上，因此 Mont 增强了 CIP 在 GO 和 rGO 上的吸附。同时，CIP 与石墨烯之间的 π-π 相互作用导致 CIP 分子中环丙基 CH 和一个环丙基发生了较大的位移。GO、rGO 和 Mont 主要通过 COOH 基团与 CIP 相互作用。CIP 和胃蛋白酶分子也可以插入并增加 Mont 的层间距。在各种吸附剂-吸附质的相互作用系统转移到模拟肠液后，GO 和 rGO 继续吸附 CIP。此外，通过静电排斥，Mont 中吸附的 CIP 被释放到溶液中。在 GO/rGO+Mont+胃蛋白酶体系中，CIP 的减少比例最低。因此，Mont 和 GO/rGO 的混合物降低了胃肠道液中的 CIP 浓度，从而减弱了 CIP 的进一步抗生素活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d69d/5451422/b272d28d4a7a/41598_2017_2620_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d69d/5451422/2b330b180e31/41598_2017_2620_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d69d/5451422/5bdee2ca9749/41598_2017_2620_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d69d/5451422/b6f84010b560/41598_2017_2620_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d69d/5451422/614956a2bee7/41598_2017_2620_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d69d/5451422/b1a928fb3f51/41598_2017_2620_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d69d/5451422/b272d28d4a7a/41598_2017_2620_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d69d/5451422/2b330b180e31/41598_2017_2620_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d69d/5451422/5bdee2ca9749/41598_2017_2620_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d69d/5451422/b6f84010b560/41598_2017_2620_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d69d/5451422/614956a2bee7/41598_2017_2620_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d69d/5451422/b1a928fb3f51/41598_2017_2620_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d69d/5451422/b272d28d4a7a/41598_2017_2620_Fig6_HTML.jpg

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