原发性高血压患者细胞内游离钙。硝苯地平和卡托普利的作用。
Free intracellular calcium in essential hypertension. Effects of nifedipine and captopril.
作者信息
Lenz T, Haller H, Lüdersdorf M, Kribben A, Thiede M, Distler A, Philipp T
机构信息
Department of Internal Medicine, Klinikum Steglitz, Freie Universität Berlin, Federal Republic of Germany.
出版信息
J Hypertens Suppl. 1985 Dec;3(3):S13-5.
The acute effects of nifedipine (20 mg sublingually) and of captopril (12.5 mg orally) on blood pressure and on platelet intracellular free calcium were investigated in 11 and 12 patients, respectively, with essential hypertension. Platelet calcium was measured by the Quin 2 method. Application of both drugs resulted in a significant fall in blood pressure within 60 min. Platelet calcium, however, was lowered by nifedipine only. There was no correlation between blood pressure reduction and changes in platelet calcium. Platelet intracellular free calcium concentration was 99 +/- 3 nmol in 30 normotensive subjects and 109 +/- 5 nmol (+/- s.e.m.) in 26 patients with essential hypertension (P < 0.05). There was a wide overlap between the values of normotensives and hypertensives. Thus there is no positive evidence of an increased platelet intracellular free calcium concentration in a large proportion of patients with essential hypertension.
分别对11例和12例原发性高血压患者研究了硝苯地平（舌下含服20毫克）和卡托普利（口服12.5毫克）对血压及血小板细胞内游离钙的急性影响。采用喹啉2法测定血小板钙。两种药物应用后60分钟内血压均显著下降。然而，仅硝苯地平可降低血小板钙。血压降低与血小板钙变化之间无相关性。30名血压正常者的血小板细胞内游离钙浓度为99±3纳摩尔，26例原发性高血压患者为109±5纳摩尔（±标准误）（P<0.05）。血压正常者和高血压患者的值有很大重叠。因此，没有确凿证据表明大部分原发性高血压患者的血小板细胞内游离钙浓度升高。
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