Kim Sang-Hoon, Choi Seong-Min, Kim Byeong C, Choi Kang-Ho, Nam Tai-Seung, Kim Joon-Tae, Lee Seung-Han, Park Man-Seok, Kim Seong J
Department of Neurology, Chonnam National University Medical School, Gwangju, Korea.
Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
Ann Dermatol. 2017 Jun;29(3):283-287. doi: 10.5021/ad.2017.29.3.283. Epub 2017 May 11.
Herpes zoster (HZ) is caused by reactivation of latent varicella-zoster virus (VZV) infection. HZ-associated aseptic meningitis, a rare complication of HZ, can require hospitalization and a long treatment period.
A retrospective study was performed to identify potential factors associated with HZ-associated aseptic meningitis development.
We included all outpatients and patients admitted in the neurology and dermatology departments of a single tertiary center, who were diagnosed with HZ for two years. Among 818 patients, 578 patients were eligible for analysis.
The demographics and potential risk factors were compared between the uncomplicated HZ group (n=554) and aseptic meningitis group (n=24). Among the potential factors, the dermatological distribution of skin rash and gender showed statistically significantly different between the two groups. Patients with craniocervical distribution of HZ accounted for 87.5% (n=21) of the aseptic meningitis group and 54.3% (n=301) of the uncomplicated HZ group (=0.043). The aseptic meningitis group had more men (66.7%, n=16) than the uncomplicated HZ group (42.8%, n=237, =0.033). Patients with craniocervical distribution had an odds ratio (OR) of 5.884 (=0.001) for developing aseptic meningitis when compared with the other dermatome involvements. Additional logistic regression analysis resulted in a fading between gender difference (=0.050) and craniocervical involvement having an OR of 5.667 for aseptic meningitis (=0.006).
In HZ patients, skin rash with craniocervical distribution and male gender were associated with a higher risk of aseptic meningitis.
带状疱疹（HZ）由潜伏的水痘-带状疱疹病毒（VZV）感染重新激活引起。HZ相关的无菌性脑膜炎是HZ的一种罕见并发症，可能需要住院治疗且治疗周期较长。
进行一项回顾性研究，以确定与HZ相关无菌性脑膜炎发生相关的潜在因素。
我们纳入了一家三级中心神经内科和皮肤科诊断为HZ达两年的所有门诊患者和住院患者。在818例患者中，578例患者符合分析条件。
比较了单纯HZ组（n = 554）和无菌性脑膜炎组（n = 24）的人口统计学特征和潜在危险因素。在潜在因素中，两组之间皮疹的皮肤分布和性别在统计学上有显著差异。HZ呈颅颈分布的患者在无菌性脑膜炎组中占87.5%（n = 21），在单纯HZ组中占54.3%（n = 301）（P = 0.043）。无菌性脑膜炎组男性（66.7%，n = 16）多于单纯HZ组（42.8%，n = 237，P = 0.033）。与其他皮节受累相比，HZ呈颅颈分布的患者发生无菌性脑膜炎的比值比（OR）为5.884（P = 0.001）。进一步的逻辑回归分析显示性别差异逐渐消失（P = 0.050），颅颈受累发生无菌性脑膜炎的OR为5.667（P = 0.006）。
在HZ患者中，皮疹呈颅颈分布和男性与无菌性脑膜炎的较高风险相关。
