Leonetti G, Gradnik R, Terzoli L, Fruscio M, Rupoli L, Cuspidi C, Sampieri L, Zanchetti A
Istituto di Clinica Medica Generale e Terapia Medica, Università di Milano, Italy.
J Hypertens Suppl. 1985 Dec;3(3):S161-3.
The effects of small doses of felodipine (10 mg twice daily) on blood pressure, renal function and sodium and water balance were studied in 11 patients with arterial hypertension. Felodipine significantly reduced systolic and diastolic blood pressure: most of the antihypertensive effect was already evident on day 1 of administration (-18/-11 mmHg) and only slightly increased during the subsequent week. Heart rate rose moderately only during day 1 of felodipine administration (+7 beats/min). Sodium excretion was increased during days 1 and 2, and no signs of water and electrolyte retention was observed in the week during which the balance study could be performed (Na, -135 +/- 65 mmol/7 days). At relatively low doses felodipine appears to be an effective antihypertensive agent, initially exerting some diuretic and natriuretic action and subsequently being devoid of a water- and sodium-retaining action.
在11例动脉高血压患者中研究了小剂量非洛地平（每日两次，每次10毫克）对血压、肾功能以及钠和水平衡的影响。非洛地平显著降低收缩压和舒张压：大部分降压作用在给药第1天就已明显（-18/-11 mmHg），在随后一周仅略有增加。仅在非洛地平给药第1天心率适度上升（+7次/分钟）。第1天和第2天钠排泄增加，在进行平衡研究的一周内未观察到水和电解质潴留迹象（钠，-135±65 mmol/7天）。在相对低剂量时，非洛地平似乎是一种有效的抗高血压药物，最初发挥一些利尿和利钠作用，随后无保水和保钠作用。
