Fagerberg B, Andersson O K, Persson B, Hedner T, Hedner J, Towle A
Department of Medicine I, Sahlgrenska Hospital, University of Gothenburg, Sweden.
J Hypertens Suppl. 1985 Dec;3(3):S327-9.
To investigate the antihypertensive effect of moderate sodium restriction, the sodium intake of 11 male outpatients was reduced by 120 mmol/day for 4-6 weeks. These patients and an untreated control group were slightly obese and had mild untreated hypertension (WHO 1-2). All subjects were examined before and at the end of the experiment. Diastolic blood pressure fell significantly in the diet group in comparison with the control group. Invasive haemodynamic examinations in the diet group showed an unchanged mean cardiac output and a reduction of mean total peripheral resistance. Plasma volume (Evan's Blue) did not change, neither did extracellular volume as calculated from determinations of tritiated water, total body potassium and body mass. During sodium restriction, plasma renin activity and urinary aldosterone excretion significantly increased. Noradrenaline and dopamine excretion in urine showed no significant changes during sodium restriction, neither did the plasma concentrations of atrial natriuretic peptides. The reduction in mean arterial blood pressure was correlated significantly with a decrease in 24-h sodium excretion and an increase in urinary aldosterone excretion. In conclusion, moderate dietary sodium restriction seems to lower blood pressure by diminishing the total peripheral resistance while cardiac output, extracellular and intravascular volumes are maintained.
为研究适度限钠的降压效果，11名男性门诊患者的钠摄入量在4至6周内每天减少120毫摩尔。这些患者和一个未接受治疗的对照组均轻度肥胖且患有未经治疗的轻度高血压（世界卫生组织1 - 2级）。所有受试者在实验开始前和结束时均接受检查。与对照组相比，饮食组的舒张压显著下降。饮食组的有创血流动力学检查显示平均心输出量未变，平均总外周阻力降低。血浆容量（伊文思蓝）未改变，根据氚标记水、总体钾和体重测定计算得出的细胞外液量也未改变。在限钠期间，血浆肾素活性和尿醛固酮排泄显著增加。限钠期间尿去甲肾上腺素和多巴胺排泄无显著变化，血浆心房利钠肽浓度也无变化。平均动脉血压的降低与24小时钠排泄的减少和尿醛固酮排泄的增加显著相关。总之，适度的饮食限钠似乎通过降低总外周阻力来降低血压，同时维持心输出量、细胞外液量和血管内容量。
