Geri A, Agabiti-Rosei E, Muiesan M L, Romanelli G, Platto L, Muiesan G
Department of Medical Sciences, University of Brescia, Italy.
J Hypertens Suppl. 1985 Dec;3(3):S335-7.
Structural vascular changes in the calf arteries and left ventricular mass were measured in 52 essential hypertensive patients (WHO I and II, 35 men and 17 women, age range 21-63 years). Left ventricular mass was measured on M-mode echocardiographic tracings. Structural vascular changes were evaluated indirectly by studying the minimal vascular resistance, calculated from mean arterial pressure and maximal (post-ischaemic) blood flow, measured by venous occlusion plethysmography. A statistically significant correlation between left ventricular mass and minimal vascular resistance was observed (r = 0.33, P < 0.05). The low correlation suggested that structural changes in the heart and in the systemic arteries did not develop simultaneously. In the subgroup of patients with minimal vascular resistance in the normal range, left ventricular hypertrophy was found in 15 out of 30 patients (50% of cases) whereas, in the subgroup of patients with high minimal vascular resistance, absence of left ventricular hypertrophy was found in six out of 22 patients (27% of cases). These results suggest that left ventricular hypertrophy more often precedes arterial structural changes in the calves.
对52例原发性高血压患者（WHO I级和II级，35名男性和17名女性，年龄范围21 - 63岁）测量了小腿动脉的结构血管变化和左心室质量。左心室质量通过M型超声心动图描记法测量。通过研究最小血管阻力间接评估结构血管变化，最小血管阻力由平均动脉压和最大（缺血后）血流计算得出，血流通过静脉阻塞体积描记法测量。观察到左心室质量与最小血管阻力之间存在统计学显著相关性（r = 0.33，P < 0.05）。低相关性表明心脏和全身动脉的结构变化并非同时发生。在最小血管阻力处于正常范围的患者亚组中，30例患者中有15例（50%）发现左心室肥厚，而在最小血管阻力高的患者亚组中，22例患者中有6例（27%）未发现左心室肥厚。这些结果表明，左心室肥厚更常先于小腿动脉结构变化出现。
