镍和铜催化由肼、邻氯（杂）二苯甲酮和（杂）芳基溴一锅法合成不对称1,3 - 二（杂）芳基 - 1H - 吲唑。
Ni and Cu-catalyzed one pot synthesis of unsymmetrical 1,3-di(hetero)aryl-1H-indazoles from hydrazine, o-chloro (hetero)benzophenones, and (hetero)aryl bromides.
作者信息
Wiethan Carson, Lavoie Christopher M, Borzenko Andrey, Clark Jillian S K, Bonacorso Helio G, Stradiotto Mark
机构信息
Departamento de Química, Universidade Federal de Santa Maria, 97105-900 Santa Maria, Brazil.
出版信息
Org Biomol Chem. 2017 Jun 14;15(23):5062-5069. doi: 10.1039/c7ob00841d.
PMID:28567460
Abstract
The nickel-catalyzed cyclization of in situ generated ortho-chlorobenzophenone hydrazone derivatives, to afford 3-(hetero)aryl-1H-indazoles, is documented for the first time. The product 1H-indazoles can be transformed subsequently in a one-pot procedure into 1,3-di(hetero)aryl-1H-indazoles via copper-catalyzed N-arylation with (hetero)aryl bromides.
摘要
首次报道了镍催化原位生成的邻氯二苯甲酮腙衍生物环化，以得到3-（杂）芳基-1H-吲唑。产物1H-吲唑随后可以通过与（杂）芳基溴化物的铜催化N-芳基化，在一锅法中转化为1,3-二（杂）芳基-1H-吲唑。
Zotero 插件