Samuelsson O, Wilhelmsen L, Pennert K, Berglund G
University of Gothenburg, Department of Medicine I, Sahlgrenska Hospital, Sweden.
J Hypertens Suppl. 1985 Dec;3(3):S497-500.
Prognostic factors for cardiovascular disease (CVD) were studied in 686 treated, middle-aged male hypertensives followed for 10 years at a hypertension clinic. The factors studied were all obtained from a standard clinical routine examination and both univariate and multivariate analyses were performed. Only entry characteristics were analysed. The 10-year incidence of any CVD event (CVD death, non-fatal myocardial infarction or non-fatal stroke) was 15.3% and of coronary heart disease (CHD) morbidity (fatal or non-fatal myocardial infarction) 12.3%. Independent predictors of CVD morbidity were diastolic blood pressure (DBP), smoking, cholesterol, proteinuria, angina pectoris and previous stroke. Except for a previous stroke the same variables were independent predictors of CHD. The findings show that in spite of treatment for hypertension, the CVD risk is still substantial if organ damage or other risk factors are present. The results underline the importance of multiple risk factor intervention in hypertensive patients.
在一家高血压诊所，对686名接受治疗的中年男性高血压患者进行了为期10年的随访，以研究心血管疾病（CVD）的预后因素。所研究的因素均来自标准临床常规检查，并进行了单变量和多变量分析。仅分析了入院时的特征。任何心血管疾病事件（心血管疾病死亡、非致命性心肌梗死或非致命性中风）的10年发病率为15.3%，冠心病（CHD）发病率（致命或非致命性心肌梗死）为12.3%。心血管疾病发病的独立预测因素为舒张压（DBP）、吸烟、胆固醇、蛋白尿、心绞痛和既往中风。除既往中风外，相同变量是冠心病的独立预测因素。研究结果表明，尽管对高血压进行了治疗，但如果存在器官损害或其他危险因素，心血管疾病风险仍然很高。结果强调了对高血压患者进行多危险因素干预的重要性。
