Rüegg U T, Doyle V M, Hof R P
Cardiovascular Unit, Preclinical Research, Sandoz Inc., Basle, Switzerland.
J Hypertens Suppl. 1985 Dec;3(3):S57-9.
A smooth muscle cell line was used for studies on the activity of the voltage-sensitive calcium channel (VSCC). Upon exposure to a depolarizing solution or to a calcium channel activator, an increase in 45Ca2+ uptake was observed. Calcium entry blockers inhibited the uptake with potencies very similar to those observed in relaxing depolarization-induced constriction of aortic rings. The two enantiomers of the dihydropyridine PN 200-110 showed about a 300-fold potency difference in blocking 45Ca2+ uptake.
一种平滑肌细胞系被用于研究电压敏感性钙通道（VSCC）的活性。当暴露于去极化溶液或钙通道激活剂时，观察到45Ca2+摄取增加。钙通道阻滞剂抑制摄取的效力与在松弛去极化诱导的主动脉环收缩中观察到的效力非常相似。二氢吡啶PN 200-110的两种对映体在阻断45Ca2+摄取方面显示出约300倍的效力差异。
