去氧皮质酮和盐摄入量对大鼠体内钠、液体摄入量、血压及钠负荷排泄的影响。

Effects of DOCA and salt intake on body sodium, fluid intake, blood pressure and excretion of a sodium load in rats.

作者信息

Simpson F O, Ledingham J M, Paulin J M, Purves R D

机构信息

Wellcome Medical Research Institute, University of Otago Medical School, Dunedin, New Zealand.

出版信息

J Hypertens Suppl. 1985 Dec;3(3):S77-8.

PMID:2856786

Abstract

Body sodium was measured repeatedly by a whole-body counting method (22Na) in control and deoxycorticosterone acetate (DOCA)-treated Wistar rats taking a sodium-free pelleted diet and drinking a choice of H2O and either 0.5% NaCl or 0.1% NaCl (n = 11 per group, four groups). Body sodium was higher in DOCA-treated than in control rats and higher in rats on 0.5% NaCl than in those on 0.1% NaCl. These differences persisted even when all sodium intake was stopped. An intraperitoneal NaCl load was excreted at least as rapidly by the DOCA-treated as by the control rats. Commencement of excretion was slower in the rats on 0.1% NaCl than in those on 0.5% NaCl. It is concluded that DOCA raises the basal level of body sodium but does not slow down the excretion of sodium in the body in excess of the basal level.

摘要

采用全身计数法（22Na），对食用无钠颗粒饲料、可选择饮用H2O以及0.5% NaCl或0.1% NaCl的对照和醋酸脱氧皮质酮（DOCA）处理的Wistar大鼠反复测量体内钠含量（每组n = 11只，共四组）。DOCA处理的大鼠体内钠含量高于对照大鼠，且食用0.5% NaCl的大鼠体内钠含量高于食用0.1% NaCl的大鼠。即使停止所有钠摄入，这些差异依然存在。腹腔注射NaCl后，DOCA处理的大鼠排泄速度至少与对照大鼠一样快。食用0.1% NaCl的大鼠排泄开始时间比食用0.5% NaCl的大鼠慢。得出的结论是，DOCA提高了体内钠的基础水平，但不会减缓体内超过基础水平的钠的排泄。