Wood P L
Neuroscience Research, Research Department, CIBA Geigy Corporation, Summit, NJ 07901.
Peptides. 1988;9 Suppl 1:49-55. doi: 10.1016/0196-9781(88)90223-9.
The study of the CNS actions of opioids is complicated by the presence of both multiple opioid receptors and endogenous ligands in the brain. The recent descriptions of opioid isoreceptors, of tonic opioid systems, and of multiple opioid receptors on a single neuron are further technical details which must be considered. In the use of various opiates and opioid peptides to study physiological systems, the multiple opioid affinities of these compounds, as well as potential non-opioid actions, must be controlled for in the experimental design. In conjunction with the multiple receptor affinities of various opiates is the problem of receptor dualism with some drugs; particularly with the agonist/antagonist analgesics. Species differences in the relative proportions of different opioid receptor populations also limit any generalizations of a finding in one species. These limitations in the study of opioid receptors will be discussed with reference to previous neurochemical, neuroendocrine, electrophysiological and behavioral reports of multiple opioid receptors.
由于大脑中存在多种阿片受体和内源性配体，阿片类药物对中枢神经系统作用的研究变得复杂。近期关于阿片类同型受体、紧张性阿片系统以及单个神经元上多种阿片受体的描述，是必须考虑的进一步技术细节。在使用各种阿片类药物和阿片肽研究生理系统时，这些化合物的多种阿片亲和力以及潜在的非阿片作用，在实验设计中必须加以控制。与各种阿片类药物的多种受体亲和力相关的是一些药物的受体二元性问题；尤其是激动剂/拮抗剂镇痛药。不同阿片受体群体相对比例的种属差异，也限制了对一个物种研究结果的任何普遍化推断。将参考先前关于多种阿片受体的神经化学、神经内分泌、电生理和行为学报告，讨论阿片受体研究中的这些局限性。
