Barnett A J, Cauchi M N, Hosking C S, Sharp A H
Aust N Z J Med. 1978 Dec;8(6):622-7. doi: 10.1111/j.1445-5994.1978.tb04851.x.
A variety of tests were performed to determine the immune status of a group of patients with scleroderma (progressive systemic sclerosis). Sera of 11 of 35 patients showed autoantibodies by an immunofluorescent technique. There was no significant difference between the C3 and C4 components of complement in 12 patients tested and laboratory controls. IgM levels were raised in 24 of 34 sera. Four of ten patients showed some deficiency of phagocytic function in the leucocyte iodination test. B cell and T cell numbers were normal in the eight patients tested. Reactivity to mitogens was usually normal in ten patients tested with a deficient response to one of the three mitogens in two patients. In skin reactivity tests in 23 patients, only one was anergic to all of the four antigens tested. It is concluded that although some immune abnormalities are common in scleroderma there is no consistent abnormality in any of the tests used. This does not exclude the possibility that immune factors may be involved in systemic manifestations of the disease, or that there may be some subtle specific abnormality not revealed by the tests performed.
进行了多种测试以确定一组硬皮病（进行性系统性硬化症）患者的免疫状态。35名患者中有11名患者的血清通过免疫荧光技术显示出自身抗体。在接受测试的12名患者中，补体的C3和C4成分与实验室对照之间没有显著差异。34份血清中有24份IgM水平升高。在白细胞碘化试验中，10名患者中有4名显示出一定程度的吞噬功能缺陷。在接受测试的8名患者中，B细胞和T细胞数量正常。在用三种有丝分裂原之一进行测试的10名患者中，对有丝分裂原的反应性通常正常，其中两名患者反应不足。在对23名患者进行的皮肤反应性测试中，只有一名患者对所有四种测试抗原无反应。结论是，虽然硬皮病中一些免疫异常很常见，但在所使用的任何测试中都没有一致的异常。这并不排除免疫因素可能参与该疾病的全身表现的可能性，也不排除可能存在一些未通过所进行的测试揭示的微妙的特定异常的可能性。
