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Clinical implications of guanine nucleotide-binding proteins as receptor-effector couplers.

作者信息

Spiegel A M, Gierschik P, Levine M A, Downs R W

出版信息

N Engl J Med. 1985 Jan 3;312(1):26-33. doi: 10.1056/NEJM198501033120106.

DOI:10.1056/NEJM198501033120106
PMID:2856889
Abstract
摘要

相似文献

1
Clinical implications of guanine nucleotide-binding proteins as receptor-effector couplers.
N Engl J Med. 1985 Jan 3;312(1):26-33. doi: 10.1056/NEJM198501033120106.
2
Genetic and functional studies of guanine nucleotide-binding regulatory proteins.
Adv Exp Med Biol. 1984;175:85-98. doi: 10.1007/978-1-4684-4805-4_7.
3
[Transmembrane signal control and guanine nucleotide-binding protein--receptor-adenylate cyclase coupling].[跨膜信号控制与鸟嘌呤核苷酸结合蛋白 - 受体 - 腺苷酸环化酶偶联]
Seikagaku. 1985 Oct;57(10):1339-60.
4
Detection of novel guanine nucleotide binding proteins in bovine retinal rod outer segments.
Biochem Biophys Res Commun. 1990 Jul 31;170(2):719-25. doi: 10.1016/0006-291x(90)92150-x.
5
Regulation of phosphoinositide breakdown by guanine nucleotides.鸟嘌呤核苷酸对磷酸肌醇分解的调节
Life Sci. 1986 Jul 21;39(3):187-94. doi: 10.1016/0024-3205(86)90529-1.
6
[Inhibitory effect of pertussis toxin on the metabolism of guanine nucleotides in transducin from bovine outer rod segments].
Biokhimiia. 1986 Jul;51(7):1216-22.
7
[Receptor-adenylate cyclase coupling--receptor-GTP binding protein(N) coupling and ADP-ribosylation of N by bacterial toxins].[受体 - 腺苷酸环化酶偶联——受体 - GTP 结合蛋白（N）偶联以及细菌毒素对 N 的 ADP 核糖基化作用]
Tanpakushitsu Kakusan Koso. 1985 Apr;30(4):303-13.
8
Pertussis toxin-catalyzed ADP-ribosylation of adenylate cyclase. Effects of guanyl nucleotides and rhodopsin.百日咳毒素催化的腺苷酸环化酶的ADP-核糖基化。鸟苷核苷酸和视紫红质的作用。
Dev Biol Stand. 1985;61:43-9.
9
[Effect of bacterial toxins on the GTPase activity of transducin from bovine rod outer segments].[细菌毒素对牛视杆细胞外段转导素GTP酶活性的影响]
Biokhimiia. 1985 Nov;50(11):1825-35.
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G proteins: a family of signal transducers.G蛋白：一类信号转导分子家族。
Annu Rev Cell Biol. 1986;2:391-419. doi: 10.1146/annurev.cb.02.110186.002135.

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Persistent activation of Gsalpha through limited proteolysis by calpain.钙蛋白酶通过有限的蛋白水解作用导致Gsα持续激活。
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Antibodies against the carboxyl-terminal 5-kDa peptide of the alpha subunit of transducin crossreact with the 40-kDa but not the 39-kDa guanine nucleotide binding protein from brain.针对转导素α亚基羧基末端5-kDa肽段的抗体与大脑中40-kDa而非39-kDa的鸟嘌呤核苷酸结合蛋白发生交叉反应。
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6
Hypertrophy of pheochromocytoma cells treated with nerve growth factor and activators of adenylate cyclase.
Cell Tissue Res. 1987 Jul;249(1):161-9. doi: 10.1007/BF00215430.
7
Multisite phosphorylation of the alpha subunit of transducin by the insulin receptor kinase and protein kinase C.转导素α亚基被胰岛素受体激酶和蛋白激酶C的多位点磷酸化。
Proc Natl Acad Sci U S A. 1986 Dec;83(24):9294-7. doi: 10.1073/pnas.83.24.9294.
8
Use of specific antibodies to quantitate the guanine nucleotide-binding protein Go in brain.使用特异性抗体对脑中鸟嘌呤核苷酸结合蛋白Go进行定量分析。
Proc Natl Acad Sci U S A. 1986 Apr;83(7):2258-62. doi: 10.1073/pnas.83.7.2258.
9
Agonist binding at alpha 2-adrenoceptors of human platelets using 3H-UK-14,304: regulation by Gpp(NH)p and cations.使用³H-UK-14,304研究激动剂与人血小板α₂-肾上腺素能受体的结合：Gpp(NH)p和阳离子的调节作用
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Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart.衰竭的人类心脏中40,000摩尔重量百日咳毒素底物（G蛋白）增加。
J Clin Invest. 1988 Jul;82(1):189-97. doi: 10.1172/JCI113569.