Guo Zhongwei, Liu Xiaozheng, Li Jiapeng, Wei Fuquan, Hou Hongtao, Chen Xingli, Li Xinwei, Chen Wei
Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, China.
China-USA Neuroimaging Research Institute, Department of Radiology of the Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
Clin Neurophysiol. 2017 Jul;128(7):1344-1349. doi: 10.1016/j.clinph.2017.05.003. Epub 2017 May 17.
To explore brain activity in AD with depression (D-AD) based on fractional amplitude of low-frequency fluctuation (fALFF).
Twenty-two D-AD and 21 AD without depression patients (nD-AD) were examined by magnetic resonance imaging during resting state. Neuropsychiatric Inventory and Hamilton Depression Rating Scale were employed to assess the severity of depression. We analysed the characteristics of fALFF in D-AD differing from nD-AD. We also examined the correlation between fALFF and the depression severity.
D-AD patients had higher fALFF in right fusiform gyrus, left caudate nucleus, and right middle temporal gyrus (MTG), meanwhile lower fALFF in supplementary motor area (SMA) than nD-AD patients.
Abnormal fALFF changes in fusiform gyrus, caudate nucleus, MTG and SMA may be important neuropathophysiologic characteristics of depression in AD.
We have clarified the potential neuropathological changes of depression in AD based on fALFF method, which is crucial for effective intervention.
基于低频振幅分数（fALFF）探讨伴发抑郁的阿尔茨海默病（D-AD）患者的脑活动情况。
对22例D-AD患者和21例无抑郁的阿尔茨海默病患者（nD-AD）在静息状态下进行磁共振成像检查。采用神经精神量表和汉密尔顿抑郁量表评估抑郁严重程度。分析D-AD患者与nD-AD患者fALFF的特征差异，并检测fALFF与抑郁严重程度之间的相关性。
与nD-AD患者相比，D-AD患者右侧梭状回、左侧尾状核及右侧颞中回（MTG）的fALFF较高，而辅助运动区（SMA）的fALFF较低。
梭状回、尾状核、MTG及SMA中fALFF的异常变化可能是AD患者抑郁的重要神经病理生理特征。
我们基于fALFF方法阐明了AD患者抑郁潜在的神经病理变化，这对有效干预至关重要。
