Popp J A, Garvey L K, Hamm T E, Swenberg J A
Carcinogenesis. 1985 Jan;6(1):141-4. doi: 10.1093/carcin/6.1.141.
The hepatocarcinogenicity of di(2-ethylhexyl)phthalate (DEHP) was demonstrated in a recent bioassay in both rats and mice. Due to the negative genotoxicity of DEHP in both in vivo and in vitro assays, it was hypothesized that the positive carcinogenic response of DEHP may have been due to a promotional effect of DEHP on spontaneous foci. However, when DEHP was used in the promotion phase of a rat hepatic initiation-promotion system, no promotional activity could be demonstrated after either 3 or 6 months of feeding DEHP at a dietary concentration of 1.2%. No neoplasms or nodules were identified. In addition, DEHP did not increase the number of foci or the mean volume of the foci when foci were identified by six different histologic stains.
邻苯二甲酸二（2-乙基己基）酯（DEHP）的肝癌致癌性在最近一项针对大鼠和小鼠的生物测定中得到证实。由于DEHP在体内和体外试验中均具有阴性遗传毒性，因此推测DEHP的阳性致癌反应可能是由于其对自发病灶的促进作用。然而，当DEHP用于大鼠肝脏启动-促进系统的促进阶段时，在以1.2%的膳食浓度喂食DEHP 3个月或6个月后，均未显示出促进活性。未发现肿瘤或结节。此外，当通过六种不同的组织学染色鉴定病灶时，DEHP并未增加病灶数量或病灶的平均体积。
