Leube Rudolf E, Moch Marcin, Windoffer Reinhard
Institute of Molecular and Cellular Anatomy, RWTH Aachen University, 52074 Aachen, Germany.
Cold Spring Harb Perspect Biol. 2017 Jun 1;9(6):a021980. doi: 10.1101/cshperspect.a021980.
SUMMARYThe establishment and continuous cell type-specific adaptation of cytoplasmic intermediate filament (IF) networks are linked to various types of IF motility. Motor protein-driven active transport, linkage to other cellular structures, diffusion of small soluble subunits, and intrinsic network elasticity all contribute to the motile behavior of IFs. These processes are subject to regulation by multiple signaling pathways. IF motility is thereby connected to and involved in many basic cellular processes guarding the maintenance of cell and tissue integrity. Disturbances of IF motility are linked to diseases that are characterized by cytoplasmic aggregates containing IF proteins together with other cellular components.
摘要
细胞质中间丝(IF)网络的建立及其持续的细胞类型特异性适应与多种类型的IF运动性相关。马达蛋白驱动的主动运输、与其他细胞结构的连接、小的可溶性亚基的扩散以及内在的网络弹性都有助于IF的运动行为。这些过程受到多种信号通路的调节。因此,IF运动性与许多维持细胞和组织完整性的基本细胞过程相关并参与其中。IF运动性的紊乱与以含有IF蛋白和其他细胞成分的细胞质聚集体为特征的疾病有关。