Sierra-Marcos Alba
Department of Neurology, Barcelona Medicine and Surgery Institute (IMECBA), Barcelona, Spain.
Alzheimer Disease Research Unit, CIEN Foundation, Queen Sofia Foundation Alzheimer Center, Madrid, Spain.
Int J Alzheimers Dis. 2017;2017:5479597. doi: 10.1155/2017/5479597. Epub 2017 Mar 1.
Alzheimer's disease (AD) depicts dynamic changes in regional brain function from early stages of the disease. Arterial spin labeling- (ASL-) based MRI methods have been applied for detecting regional cerebral blood flow (rCBF) perfusion changes in patients with AD and mild cognitive impairment (MCI). Nevertheless, the results obtained from ASL studies in AD and MCI are still controversial, since rCBF maps may show both hypoperfusion or hyperperfusion areas in brain structures involved in different cognitive functions. The goal of this review is to provide the current state of the art regarding the role of ASL for detecting distinctive perfusion patterns in subjects with MCI and/or AD. The ability to obtain this information using a noninvasive and widely available modality such as ASL should greatly enhance the knowledge into the broad range of hemodynamically related changes taking place during the cognitive decline process in AD.
阿尔茨海默病(AD)在疾病早期阶段呈现出区域脑功能的动态变化。基于动脉自旋标记(ASL)的磁共振成像(MRI)方法已被用于检测AD和轻度认知障碍(MCI)患者的区域脑血流(rCBF)灌注变化。然而,AD和MCI的ASL研究结果仍存在争议,因为rCBF图可能在参与不同认知功能的脑结构中显示灌注不足或灌注过度区域。本综述的目的是提供关于ASL在检测MCI和/或AD患者独特灌注模式方面作用的当前技术水平。使用诸如ASL这样的非侵入性且广泛可用的方式获取此信息的能力,应极大地增强我们对AD认知衰退过程中发生的广泛血流动力学相关变化的认识。