Xu Y, Chen L L, Su Y, Sun S N, Zhang H Y
Department of Neurology, Northern Jiangsu People's Hospital, Yangzhou 225001, China.
Medical Imaging Department, Northern Jiangsu People's Hospital, Yangzhou 225001, China.
Zhonghua Yi Xue Za Zhi. 2019 Jan 15;99(3):193-197. doi: 10.3760/cma.j.issn.0376-2491.2019.03.008.
To analyze the relationships between cerebral blood perfusion and impairments of cognitive function in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). A total of 21 patients with AD, 18 patients with MCI and 21 healthy adults as control group (NC group) matched in age, gender and education were recruited between November 2016 and November 2017 from Northern Jiangsu People's Hospital. All cases were performed routine head MRI, arterial spin labeling (ASL). Cognitive function evaluation including simple mental state scale (MMSE) and improved Addenbrooke's cognitive examination revised (ACE-R) of patients were also assessed. The difference between cerebral blood perfusion signals and cognitive impairment of the three groups were analyzed. The subtest scores of attention and orientation, memory, language fluency, language and visual space of ACE-R scores were significantly reduced (0.001,uncorrected) for AD when compared with MCI. Using REST1.8 software to perform single factor ANOVA, and adjusted for 0.05. The AD group showed a decrease in total cerebral perfusion compared to the NC group, a decrease and in the frontotemporal lobe compared to MCI group; compared with the normal group, MCI group also showed decreased perfusion in frontotemporal cortex. correlation analysis was performed on the cerebral blood flow and ACE-R scores in the AD group and the MCI group,the decrease degree of CBF in multiple brain regions was positively correlated with the total score of ACE-R's total scores, and the subtest score of ACE-R including attention and orientation, memory, language fluency, language and visual space also showed positive correlation. ASL technology can detect the changes of cerebral blood flow metabolism in AD and MCI patients, and reveal association relationships between brain function damage and cerebral blood flow metabolism in AD and MCI patients.
分析阿尔茨海默病（AD）和轻度认知障碍（MCI）患者脑血流灌注与认知功能损害之间的关系。2016年11月至2017年11月期间，从苏北人民医院招募了21例AD患者、18例MCI患者和21名年龄、性别和教育程度相匹配的健康成年人作为对照组（NC组）。所有病例均进行常规头部MRI、动脉自旋标记（ASL）检查。还对患者进行了认知功能评估，包括简易精神状态量表（MMSE）和改良版Addenbrooke认知检查修订版（ACE-R）。分析三组脑血流灌注信号与认知障碍之间的差异。与MCI相比，AD患者ACE-R评分的注意力与定向、记忆、语言流畅性、语言及视觉空间等子测试分数显著降低（P<0.001，未校正）。使用REST1.8软件进行单因素方差分析，并校正P值为0.05。与NC组相比，AD组全脑灌注减少；与MCI组相比，AD组额颞叶灌注减少；与正常组相比，MCI组额颞叶皮质灌注也减少。对AD组和MCI组的脑血流量与ACE-R评分进行相关性分析，多个脑区脑血流量的降低程度与ACE-R总分呈正相关，ACE-R包括注意力与定向、记忆、语言流畅性、语言及视觉空间等子测试分数也呈正相关。ASL技术可检测AD和MCI患者脑血流代谢的变化，并揭示AD和MCI患者脑功能损害与脑血流代谢之间的关联关系。
