低丙种球蛋白血症患者癌症的前瞻性研究。
Prospective study of cancer in patients with hypogammaglobulinaemia.
作者信息
Kinlen L J, Webster A D, Bird A G, Haile R, Peto J, Soothill J F, Thompson R A
出版信息
Lancet. 1985 Feb 2;1(8423):263-6. doi: 10.1016/s0140-6736(85)91037-2.
Among 377 patients with primary hypogammaglobulinaemia, mainly common variable immunodeficiency (CVID), 316 patients survived the first 2 years after diagnosis and were the subject of a study of cancer incidence. Among the 220 patients with CVID, there was a 5-fold increase of cancer due mainly to large excesses of stomach cancer (47-fold) and lymphomas (30-fold). The excess of stomach cancer is probably related to the high frequency of achlorhydria in CVID. 3 of the 7 patients with stomach cancer and CVID survived for 5 years or longer.
在377例原发性低丙种球蛋白血症患者中，主要是常见变异型免疫缺陷病（CVID），316例患者在诊断后的头两年存活下来，并成为癌症发病率研究的对象。在220例CVID患者中，癌症发病率增加了5倍，主要是由于胃癌（47倍）和淋巴瘤（30倍）的大量增加。胃癌的增加可能与CVID中胃酸缺乏的高频率有关。7例患有胃癌和CVID的患者中有3例存活了5年或更长时间。
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