室温下一氧化碳、伯胺和醛的还原偶联：一种合成不对称N,N-二取代甲酰胺的通用方法。
Reductive Coupling of CO , Primary Amine, and Aldehyde at Room Temperature: A Versatile Approach to Unsymmetrically N,N-Disubstituted Formamides.
作者信息
Ke Zhengang, Hao Leiduan, Gao Xiang, Zhang Hongye, Zhao Yanfei, Yu Bo, Yang Zhenzhen, Chen Yu, Liu Zhimin
机构信息
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Colloid, Interface and Thermodynamics, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
出版信息
Chemistry. 2017 Jul 21;23(41):9721-9725. doi: 10.1002/chem.201701420. Epub 2017 Jun 28.
We present a simple, metal-free, and versatile route to synthesize unsymmetrically N,N-disubstituted formamides (NNFAs) from CO , primary amine, and aldehyde promoted by an ionic liquid (1-butyl-3-methylimidazolium chloride) at room temperature. This approach features wide scopes of amines and aldehydes, and various unsymmetrical NNFAs could be obtained in good to excellent yields. The ionic liquid can be reused for at least five runs without obvious activity loss.
我们展示了一种简单、无金属且通用的方法，可在室温下通过离子液体（1-丁基-3-甲基咪唑氯盐）促进，由一氧化碳、伯胺和醛合成不对称N,N-二取代甲酰胺（NNFAs）。该方法具有广泛的胺和醛的适用范围，并且可以以良好至优异的产率获得各种不对称NNFAs。离子液体可以重复使用至少五次而没有明显的活性损失。
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