Appleyard S T, Dunn M J, Dubowitz V, Rose M L
Lancet. 1985 Feb 16;1(8425):361-3. doi: 10.1016/s0140-6736(85)91384-4.
The distribution of HLA ABC class I antigens in human skeletal muscle obtained by needle biopsy was investigated by means of a monoclonal antibody (W6/32) and an immunoperoxidase technique. Five samples from normal individuals and twenty-nine from patients with various neuromuscular disorders were examined. Normal muscle fibres and those from patients with congenital muscular dystrophy expressed little or no class I antigens, whereas muscle fibres of patients with myositis and various X-linked muscular dystrophies showed consistently strong expression. In other neuromuscular diseases expression was more variable. The presence of class I antigens on diseased muscle fibres may render them susceptible to cytotoxic T cells; these antigens may thus have an important role in the destruction of muscle fibres.
采用单克隆抗体（W6/32）和免疫过氧化物酶技术，研究了通过针吸活检获得的人骨骼肌中HLA ABC I类抗原的分布。检查了5例正常个体的样本和29例患有各种神经肌肉疾病患者的样本。正常肌纤维以及先天性肌营养不良患者的肌纤维表达很少或不表达I类抗原，而肌炎和各种X连锁肌营养不良患者的肌纤维则始终显示出强烈的表达。在其他神经肌肉疾病中，表达变化更大。患病肌纤维上I类抗原的存在可能使它们易受细胞毒性T细胞的攻击；因此，这些抗原可能在肌纤维的破坏中起重要作用。
