Autism Research Centre, Bloorview Research Institute/University of Toronto, Toronto, ON.
Departments of Pediatrics and Psychology & Neuroscience, Dalhousie University, Halifax, NS.
Autism Res. 2017 Oct;10(10):1700-1711. doi: 10.1002/aur.1818. Epub 2017 Jun 2.
To evaluate the efficacy of the Social ABCs parent-mediated intervention for toddlers with suspected or confirmed autism spectrum disorder (ASD), through a cross-site randomized control trial, sixty-three parent-toddler dyads (toddler age: 16-30 months) were randomized into treatment (Social ABCs) or control (service-as-usual) conditions. Video data were obtained at three key time-points: Baseline; Post-training (PT; week 12); and Follow-Up (week 24). Analyses included 62 dyads. Treatment allocation significantly accounted for PT gains, all favouring the Treatment group, in (1) child functional vocal responsiveness to parent prompts (R = 0.43, P < .001), (2) child vocal initiations (R = 0.28, P < .001), (3) parent smiling (R = 0.09, P = .017), and (4) fidelity of implementation (R = 0.71, P < .001). A trend was observed for increased social orienting (R = 0.06, P = 0.054); gains in parent smiling significantly predicted increases in child smiling and social orienting. Parents in the treatment condition reported significant gains in self-efficacy following the intervention (P = 0.009). No differential effects emerged for performance on standardized measures. The Social ABCs is a relatively low-resource, efficacious intervention, with potential to be a cost-effective means of intervening at the first signs of possible ASD. Autism Res 2017, 10: 1700-1711. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Clinical Trial Title: Social ABCs for Toddlers with Signs of Autism Spectrum Disorder: RCT of a Parent-Mediated Intervention http//ClinicalTrials.gov identifier: NCT02428452.
为了评估社会 ABC 家长介导干预对疑似或确诊自闭症谱系障碍（ASD）幼儿的疗效，通过一项跨站点随机对照试验，将 63 对家长-幼儿对子（幼儿年龄：16-30 个月）随机分为治疗（社会 ABC）或对照组（常规服务）。在三个关键时间点获取视频数据：基线；培训后（PT；第 12 周）；和随访（第 24 周）。分析包括 62 对。治疗分配显著解释了 PT 收益，所有这些都有利于治疗组，在（1）儿童对父母提示的功能性发声反应（R=0.43，P<0.001），（2）儿童发声发起（R=0.28，P<0.001），（3）家长微笑（R=0.09，P=0.017），和（4）实施保真度（R=0.71，P<0.001）。观察到社会定向（R=0.06，P=0.054）增加的趋势；家长微笑的增加显著预测了儿童微笑和社会定向的增加。接受干预后，治疗组的家长自我效能感显著提高（P=0.009）。在标准化测量上没有出现差异效果。社会 ABC 是一种相对资源较少、有效的干预措施，有可能成为早期干预自闭症的一种具有成本效益的手段。自闭症研究 2017, 10: 1700-1711。©2017 国际自闭症研究协会，威利期刊，公司。临床试验标题：社会 ABC 对有自闭症谱系障碍迹象的幼儿：家长介导干预的 RCT http//ClinicalTrials.gov 标识符：NCT02428452。
