Song Wei, Tian Chuan, Wang Kai, Zhang Run-Jin, Zou Shu-Bing
Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Department of Nuclear Medicine, Guizhou Provincial People's Hospital, Guiyang, China.
PLoS One. 2017 Jun 2;12(6):e0178762. doi: 10.1371/journal.pone.0178762. eCollection 2017.
Recently, the preoperative platelet to lymphocyte ratio (PLR) has been found reported to predict oncologic outcomes in multiple malignancies. However, its prognostic value in patients with pancreatic cancer (PC) remains controversial. The aim of this study was to assess the prognostic value of preoperative PLR in PC.
MEDLINE, EMBASE, and Cochrane databases were searched to identify studies evaluating the prognostic significance of preoperative PLR in PC. Pooled hazard ratios (HRs) for overall survival (OS) were calculated using fixed-effects/random-effects models.
A total of eight studies comprising 1,904 patients with PC were included in the meta-analysis. The pooled analysis demonstrated that elevated PLR had an association with decreased OS (HR: 1.22, 95% CI: 1.04-1.43, p = 0.02). Subgroup analysis showed that a high PLR significantly predicted poor OS in Asian studies (HR: 1.25, 95% CI: 1.03-1.52, p = 0.02), patients with metastatic disease (HR: 1.34, 95% CI: 1.01-1.77, p = 0.04) and patients with PLR >150 (HR: 1.73, 95% CI: 1.21-2.49, p = 0.003).
The preoperative PLR may be a significant independent prognostic factor in patients with PC.
最近，有报道称术前血小板与淋巴细胞比率（PLR）可预测多种恶性肿瘤的肿瘤学结局。然而，其在胰腺癌（PC）患者中的预后价值仍存在争议。本研究的目的是评估术前PLR在PC中的预后价值。
检索MEDLINE、EMBASE和Cochrane数据库，以识别评估术前PLR在PC中预后意义的研究。使用固定效应/随机效应模型计算总生存期（OS）的合并风险比（HR）。
荟萃分析共纳入了八项研究，包括1904例PC患者。汇总分析表明，PLR升高与OS降低相关（HR：1.22，95%CI：1.04-1.43，p = 0.02）。亚组分析显示，在亚洲研究中，高PLR显著预测OS较差（HR：1.25，95%CI：1.03-1.52，p = 0.02），在转移性疾病患者中（HR：1.34，95%CI：1.01-1.77，p = 0.04）以及PLR>150的患者中（HR：1.73，95%CI：1.21-2.49，p = 0.
