Gannon J A, Guinan E M, Doyle S L, Beddy P, Reynolds J V, Hussey J
Discipline of Physiotherapy, School of Medicine, Trinity College Dublin, Dublin, Ireland.
Department of Radiology.
Dis Esophagus. 2017 Aug 1;30(8):1-7. doi: 10.1093/dote/dox018.
Reduced physical functioning is common following resections for esophageal cancer; however, objective data on physical performance outcomes in this cohort are rare. The aim of this study was to assess the physical performance and health related quality of life (HRQOL) of disease free survivors and compare findings in a case matched noncancer control group. Twenty-five males (mean (±SD) aged 63 (±6) years) who were over 6 months postesophagectomy and disease-free were compared with 25 controls (60 ± 6 years). Physical functioning was assessed through hand grip strength (dynamometry), exercise capacity (incremental shuttle walk test), physical activity levels (RT3 accelerometer), and body composition (bio-electrical impedance analysis). Health-related quality of life was measured using the EORTC QLQ-C30 questionnaire. Esophageal cancer survivors demonstrated significantly lower fitness (P < 0.001) and time spent in moderate (P < 0.001) and vigorous (P < 0.001) intensity physical activity compared with controls. Global health status and quality of life were similar in both groups (P = 0.245); however, physical and role functioning domains were lower in the cancer survivors (P < 0.001, and P = 0.001, respectively). These data show that disease-free survivors of curative esophageal cancer treatment demonstrate a significant compromise in physical functioning compared with controls, thus highlighting the multiple, complex rehabilitative needs of this cohort.
食管癌切除术后身体功能下降很常见；然而，关于该队列身体机能结果的客观数据却很少见。本研究的目的是评估无病幸存者的身体机能和健康相关生活质量（HRQOL），并在病例匹配的非癌症对照组中比较结果。将25名男性（平均（±标准差）年龄63（±6）岁）纳入研究，这些男性在食管切除术后超过6个月且无疾病，与25名对照组（60±6岁）进行比较。通过握力（测力计）、运动能力（递增往返步行测试）、身体活动水平（RT3加速度计）和身体成分（生物电阻抗分析）评估身体功能。使用欧洲癌症研究与治疗组织QLQ-C30问卷测量健康相关生活质量。与对照组相比，食管癌幸存者的体能（P<0.001）以及中度（P<0.001）和剧烈（P<0.001）强度身体活动的时间明显更低。两组的总体健康状况和生活质量相似（P=0.245）；然而，癌症幸存者的身体和角色功能领域较低（分别为P<0.001和P=0.001）。这些数据表明，与对照组相比，食管癌根治性治疗的无病幸存者在身体功能方面有显著损害，从而突出了该队列复杂多样的康复需求。
